Gene Symbol | HEXIM2 |
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Entrez Gene | 124790 |
Alt Symbol | L3 |
Species | Human |
Gene Type | protein-coding |
Description | hexamethylene bis-acetamide inducible 2 |
Other Description | MAQ1 paralog|hexamethylene bis-acetamide-inducible protein 2|hexamethylene-bis-acetamide-inducible transcript 2|protein HEXIM2 |
Swissprots | D3DX66 Q96MH2 |
Accessions | EAW51541 EAW51542 Q96MH2 AA223138 AK056946 BAB71319 AK096785 AW340131 AY598322 AAT06733 BC003531 AAH03531 BC012474 AAH12474 BC025970 AAH25970 BG696988 BI829228 BI829844 BP209696 BP398345 BU501076 CA312679 CN425800 DB160394 HQ447675 ADQ32160 HY007091 XM_006721687 XP_006721750 XM_011524302 XP_011522604 XM_011524303 XP_011522605 XM_011524304 XP_011522606 XM_011524305 XP_011522607 XM_011524306 XP_011522608 XM_011524307 XP_011522609 XM_011524308 XP_011522610 NM_001303436 NP_001290365 NM_001303437 NP_001290366 NM_001303438 NP_001290367 NM_001303439 NP_001290368 NM_001303440 NP_001290369 NM_001303441 NP_001290370 NM_001303442 NP_001290371 NM_001303443 NP_001290372 NM_001303444 NP_001290373 NM_144608 NP_653209 |
Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15994294}. |
Tissue Specificity | Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed. {ECO:0000269|PubMed:15713661}. |
HEXIM2 CRISPR/Cas9 KO Plasmid (h) - sc-405971 from Santa Cruz Biotechnology
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HEXIM2 HDR Plasmid (h) - sc-405971-HDR from Santa Cruz Biotechnology
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HEXIM2 Double Nickase Plasmid (h) - sc-405971-NIC from Santa Cruz Biotechnology
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HEXIM2 Double Nickase Plasmid (h2) - sc-405971-NIC-2 from Santa Cruz Biotechnology
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HEXIM2 CRISPR Activation Plasmid (h) - sc-405971-ACT from Santa Cruz Biotechnology
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HEXIM2 CRISPR Activation Plasmid (h2) - sc-405971-ACT-2 from Santa Cruz Biotechnology
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HEXIM2 Lentiviral Activation Particles (h) - sc-405971-LAC from Santa Cruz Biotechnology
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HEXIM2 Lentiviral Activation Particles (h2) - sc-405971-LAC-2 from Santa Cruz Biotechnology
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HEXIM2 siRNA (h) - sc-60789 from Santa Cruz Biotechnology
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HEXIM2 shRNA Plasmid (h) - sc-60789-SH from Santa Cruz Biotechnology
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HEXIM2 shRNA (h) Lentiviral Particles - sc-60789-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU135941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10004 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10004 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01188 from Sigma-Aldrich
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HEXIM2 siRNA (Human) - CRJ4783 from Cohesion Biosciences
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HEXIM2 - MBS8232370 from MyBioSource
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shRNA set against Human HEXIM2 (NM_144608.1) - SHH311813 from Creative biogene
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Human HEXIM2 siRNA - orb275284 from Biorbyt
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HEXIM2 shRNA Plasmid (Human) - CHJ4783 from Cohesion Biosciences
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HEXIM2 miRNA 3'UTR clone - MiUTR1H-04471 from Creative biogene
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