POGLUT1

Gene Symbol POGLUT1
Entrez Gene 56983
Alt Symbol C3orf9, CLP46, KDELCL1, KTELC1, MDS010, MDSRP, Rumi, hCLP46
Species Human
Gene Type protein-coding
Description protein O-glucosyltransferase 1
Other Description 9630046K23Rik|CAP10-like 46 kDa protein|KDELC family like 1|KTEL (Lys-Tyr-Glu-Leu) containing 1|KTEL motif-containing protein 1|O-glucosyltransferase Rumi homolog|hRumi|myelodysplastic syndromes relative protein|protein O-xylosyltransferase|x 010 protein
Swissprots Q8NBL1 Q8N2T1 Q53GJ4 B2RD13
Accessions CAI72128 EAW79570 Q8NBL1 AF168711 AAF87313 AK027012 AK075444 BAC11625 AK126736 AK222937 BAD96657 AK295984 BAG58759 AK301002 BAG62621 AK315367 BAG37760 AY298903 AAP56253 AY358581 AAQ88944 BC030614 AAH30614 BC048810 AAH48810 BP347179 CD517010 HQ447221 ADQ31708 XM_006713704 XP_006713767 XM_006713705 XP_006713768 XM_011512997 XP_011511299 NM_152305 NP_689518 NR_024265
Function Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding. {ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:21490058, ECO:0000269|PubMed:21949356}.
Subcellular Location Endoplasmic reticulum lumen {ECO:0000269|PubMed:16524674, ECO:0000269|PubMed:24387993}.
Tissue Specificity Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level). {ECO:0000269|PubMed:16524674, ECO:0000269|PubMed:24387993}.
Top Pathways Other types of O-glycan biosynthesis

KTELC1 (L-13) - sc-99849 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

KTELC1 (N-14) - sc-99850 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-KTEL1 antibody - ab102826 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-KTEL1 antibody (ab102826) at 1/100 dilution + T47D cell line lysates at 35 µg

Anti-KTEL1 antibody [EPR10564] - ab167404 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR10564
All lanes : Anti-KTEL1 antibody [EPR10564] (ab167404) at 1/1000 dilutionLane 1 : Fetal Liver lysateLane 2 : Human small intestine lysateLane 3 : HepG2 lysateLane 4 : T47-D lysateLane 5 : HeLa lysateLysates/proteins at 10 µg per lane.

Anti-KTEL1 antibody - N-terminal - ab179423 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KTEL1 antibody - N-terminal (ab179423) at 1 µg/ml + Jurkat whole cell lysate at 10 µg

Anti-POGLUT1 Antibody (aa24-388, clone 12K155) - LS-C182925 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 12K155

Anti-POGLUT1 Antibody (aa360-390, AP) - LS-C261623 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POGLUT1 Antibody (aa360-390, Biotin) - LS-C261624 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POGLUT1 Antibody (aa360-390, APC) - LS-C261625 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POGLUT1 Antibody (aa360-390, FITC) - LS-C261626 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POGLUT1 Antibody (aa360-390, Azide-free, HRP) - LS-C261627 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POGLUT1 Antibody (aa360-390, PE) - LS-C261629 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POGLUT1 Antibody (aa360-390) - LS-C329753 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POGLUT1 Antibody (N-Terminus) - LS-C201590 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Jurkat. POGLUT1 antibody dilution 1.0 ug/ml.

Anti-POGLUT1 Antibody (aa353-382) - LS-C165653 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of KTEL1 Antibody in T47D cell line lysates (35 ug/lane). KTEL1 (arrow) was detected using the purified antibody.

Protein O-Glucosyltransferase 1/POGLUT1/KTELC1 Antibody (737512) - MAB64371 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 737512
Protein O‑Glucosyltransferase 1/POGLUT was detected in immersion fixed paraffin-embedded sections of human liver using Mouse Anti-Human Protein O‑Glucosyltransferase 1/POGLUT Monoclonal Antibody (Catalog # MAB64371) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm of hepatocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Protein O-Glucosyltransferase 1/POGLUT1/KTELC1 Antibody (737509) - MAB6437 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 737509
Western blot shows lysates of JEG‑3 human epithelial choriocarcinoma cell line. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Protein O‑Glucosyltransferase 1/POGLUT Monoclonal Antibody (Catalog # MAB6437) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Protein O‑Glucosyltransferase 1/POGLUT at approximately 46 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Protein O-Glucosyltransferase 1/POGLUT1/KTELC1 Antibody - AF6437 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
Western Blot Protein O-Glucosyltransferase 1/POGLUT1/KTELC1 Antibody

Protein O-Glucosyltransferase 1/POGLUT1/KTELC1 Antibody - NBP1-90311 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Protein O-Glucosyltransferase 1/POGLUT1/KTELC1 Antibody [NBP1-90311] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Anti-POGLUT1 antibody produced in rabbit - HPA037855 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KTELC1: <B>Cat. No. HPA037855</B>: Immunohistochemical staining of human placenta shows moderate cytoplasmic positivity in trophoblastic cells.

ANTI-KTEL1 (C-TERM) antibody produced in rabbit - SAB1304507 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KTEL1 (C-term): <B>Cat. No. SAB1304507</B>: Western blot analysis of KTEL1 Antibody (C-term) in T47D cell line lysates (35 μg/lane).

POGLUT1 Antibody - N-terminal region (ARP51191_P050) - ARP51191_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KTEL1-Antibody-C-term - AP9678b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of KTEL1 Antibody (C-term) (Cat. #AP9678b) in T47D cell line lysates (35ug/lane). KTEL1 (arrow) was detected using the purified Pab.

KTELC1 Antibody - C-terminal region (OAAB06274) - OAAB06274 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Human Protein O-Glucosyltransferase 1/POGLUT1 Antibody - AF6437 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Detection of Human Protein O-Glucosyltransferase 1/POGLUT1 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, Jurkat human acute T cell leukemia cell line, and IMR-32 human neuroblastoma cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Protein O-Glucosyltransferase 1/POGLUT1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6437) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). A specific band was detected for Protein O-Glucosyltransferase 1/POGLUT1 at approximately 46 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 .
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