| Gene Symbol |
RBSN
|
| Entrez Gene |
64145
|
| Alt Symbol |
Rabenosyn-5, ZFYVE20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
rabenosyn, RAB effector
|
| Other Description |
110 kDa protein|FYVE finger-containing Rab5 effector protein rabenosyn-5|RAB effector RBSN|rabenosyn-5|zinc finger, FYVE domain containing 20
|
| Swissprots |
Q59EY8 C9J4P5 Q8NAQ1 Q9H1K0 Q3KP30 B4DWY8
|
| Accessions |
EAW64220 EAW64221 Q9H1K0 AB209673 BAD92910 AK054598 AK092312 BAC03860 AK291288 BAF83977 AK301735 BAG63200 AL833545 AY009133 AAG33246 BC032628 BC106940 AAI06941 BF513881 BX111409 BX640925 CAE45963 DA320360 XM_005265384 XP_005265441 XM_005265385 XP_005265442 XM_005265386 XP_005265443 XM_005265387 XP_005265444 XM_011534001 XP_011532303 XM_011534002 XP_011532304 NM_001302378 NP_001289307 NM_022340 NP_071735 NR_126155
|
| Function |
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}.
|
| Subcellular Location |
Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane {ECO:0000269|PubMed:22308388}; Lipid-anchor. Note=Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface. {ECO:0000269|PubMed:22308388}.
|
| Top Pathways |
Endocytosis
|