RBSN

Gene Symbol	RBSN
Entrez Gene	64145
Alt Symbol	Rabenosyn-5, ZFYVE20
Species	Human
Gene Type	protein-coding
Description	rabenosyn, RAB effector
Other Description	110 kDa protein|FYVE finger-containing Rab5 effector protein rabenosyn-5|RAB effector RBSN|rabenosyn-5|zinc finger, FYVE domain containing 20
Swissprots	Q59EY8 C9J4P5 Q8NAQ1 Q9H1K0 Q3KP30 B4DWY8
Accessions	EAW64220 EAW64221 Q9H1K0 AB209673 BAD92910 AK054598 AK092312 BAC03860 AK291288 BAF83977 AK301735 BAG63200 AL833545 AY009133 AAG33246 BC032628 BC106940 AAI06941 BF513881 BX111409 BX640925 CAE45963 DA320360 XM_005265384 XP_005265441 XM_005265385 XP_005265442 XM_005265386 XP_005265443 XM_005265387 XP_005265444 XM_011534001 XP_011532303 XM_011534002 XP_011532304 NM_001302378 NP_001289307 NM_022340 NP_071735 NR_126155
Function	Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}.
Subcellular Location	Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane {ECO:0000269|PubMed:22308388}; Lipid-anchor. Note=Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface. {ECO:0000269|PubMed:22308388}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Rabenosyn 5 peptide - ab45507 from Abcam Category Peptide Species Human

RBSN / Rabenosyn 5 Antibody Blocking Peptide - LS-E25583 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RBSN / Rabenosyn 5 Antibody Blocking Peptide - LS-E14308 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Rabenosyn 5 blocking peptide - GTX89692-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

ZFYVE20 Blocking Peptide - 33R-5751 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Rabenosyn 5 Peptide - AC21-0412-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Rabenosyn 5 Peptide - 46-259P from ProSci Category Peptide Species Human

ZFYVE20 fusion protein - ag17554 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Rabenosyn-5(ZFYVE20) - CSB-YP884441HU CSB-EP884441HU CSB-BP884441HU CSB-MP884441HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Rabenosyn 5, Peptide - MBS426040 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Rabenosyn 5 Protein - NBP1-92310PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ZFYVE20-Blocking-Peptide-N-Term - BP21374a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ZFYVE20 Peptide, Human - M34GP17815H from Creative Peptides Category Peptide Source Synthetic. Species Human

Rabenosyn-5 (541-552) - ta-174 from Creative Peptides Category Peptide Source Homo sapiens (human)

Rabenosyn 5 Blocking Peptide - CBP4869 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Rabenosyn-5 (ZFYVE20), Recombinant Protein - MBS1290669 from MyBioSource Category Protein Prices $1,600.00, $1,600.00, $1,830.00, $1,830.00, $2,750.00, $2,750.00, $3,210.00, $3,210.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Rabenosyn 5 peptide - orb316013 from Biorbyt Category Peptide

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