| Gene Symbol | RBSN |
|---|---|
| Entrez Gene | 64145 |
| Alt Symbol | Rabenosyn-5, ZFYVE20 |
| Species | Human |
| Gene Type | protein-coding |
| Description | rabenosyn, RAB effector |
| Other Description | 110 kDa protein|FYVE finger-containing Rab5 effector protein rabenosyn-5|RAB effector RBSN|rabenosyn-5|zinc finger, FYVE domain containing 20 |
| Swissprots | Q59EY8 C9J4P5 Q8NAQ1 Q9H1K0 Q3KP30 B4DWY8 |
| Accessions | EAW64220 EAW64221 Q9H1K0 AB209673 BAD92910 AK054598 AK092312 BAC03860 AK291288 BAF83977 AK301735 BAG63200 AL833545 AY009133 AAG33246 BC032628 BC106940 AAI06941 BF513881 BX111409 BX640925 CAE45963 DA320360 XM_005265384 XP_005265441 XM_005265385 XP_005265442 XM_005265386 XP_005265443 XM_005265387 XP_005265444 XM_011534001 XP_011532303 XM_011534002 XP_011532304 NM_001302378 NP_001289307 NM_022340 NP_071735 NR_126155 |
| Function | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Subcellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane {ECO:0000269|PubMed:22308388}; Lipid-anchor. Note=Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface. {ECO:0000269|PubMed:22308388}. |
| Top Pathways | Endocytosis |
Rabenosyn-5 CRISPR/Cas9 KO Plasmid (h) - sc-410091 from Santa Cruz Biotechnology
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Rabenosyn-5 HDR Plasmid (h) - sc-410091-HDR from Santa Cruz Biotechnology
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Rabenosyn-5 Double Nickase Plasmid (h) - sc-410091-NIC from Santa Cruz Biotechnology
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Rabenosyn-5 Double Nickase Plasmid (h2) - sc-410091-NIC-2 from Santa Cruz Biotechnology
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Rabenosyn-5 CRISPR Activation Plasmid (h) - sc-410091-ACT from Santa Cruz Biotechnology
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Rabenosyn-5 CRISPR Activation Plasmid (h2) - sc-410091-ACT-2 from Santa Cruz Biotechnology
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Rabenosyn-5 Lentiviral Activation Particles (h) - sc-410091-LAC from Santa Cruz Biotechnology
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Rabenosyn-5 Lentiviral Activation Particles (h2) - sc-410091-LAC-2 from Santa Cruz Biotechnology
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Rabenosyn-5 siRNA (h) - sc-76333 from Santa Cruz Biotechnology
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Rabenosyn-5 shRNA Plasmid (h) - sc-76333-SH from Santa Cruz Biotechnology
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Rabenosyn-5 shRNA (h) Lentiviral Particles - sc-76333-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU000891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23205 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23205 from Sigma-Aldrich
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ZFYVE20 siRNA (Human) - CRJ1943 from Cohesion Biosciences
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Rabenosyn 5 RNAi - H00064145-R01 from Novus Biologicals
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ZFYVE20 - MBS8222871 from MyBioSource
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shRNA set against Human ZFYVE20 (NM_022340.2) - SHH452480 from Creative biogene
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shRNA set against Human ZFYVE20(NM_022340.2) - SHL152400 from Creative biogene
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Human ZFYVE20 siRNA - orb272444 from Biorbyt
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ZFYVE20 shRNA Plasmid (Human) - CHJ1943 from Cohesion Biosciences
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ZFYVE20 miRNA 3'UTR clone - MiUTR1H-11445 from Creative biogene
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