Gene Symbol | KIF1B |
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Entrez Gene | 23095 |
Alt Symbol | CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1 |
Species | Human |
Gene Type | protein-coding |
Description | kinesin family member 1B |
Other Description | kinesin superfamily protein KIF1B|kinesin-like protein KIF1B |
Swissprots | Q9P280 A6NFS8 O60333 Q9BV80 Q4VXC5 Q4VXC6 Q4VXC3 A6NKQ4 Q96Q94 Q4VXC4 |
Accessions | CAC16629 EAW71641 EAW71642 EAW71643 EAW71644 EAW71645 O60333 AA609163 AB011163 BAA25517 AB017133 BAB69038 AB040881 BAA95972 AB088210 BAE02543 AB088211 BAE02544 AB088212 BAE02545 AB088213 BAE02546 AF257176 AAK49332 AK022977 BAB14341 AK023184 AK025761 AK025771 AK074279 AK297439 BAG59865 AK308121 AU121683 AV726155 AY043362 AAK85155 AY139835 AAN17742 BC001415 AAH01415 BC028114 BC040017 BC047632 BC063684 BC073883 BC094856 BC115395 AAI15396 BF940695 BI601300 BP239973 BT007174 AAP35838 BU626971 DA113609 DA485632 DA774937 NM_015074 NP_055889 NM_183416 NP_904325 |
Function | Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. {ECO:0000269|PubMed:18334619}. |
Subcellular Location | Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Mitochondrion {ECO:0000269|PubMed:16225668}. Note=Colocalizes with synaptophysin at synaptic cytoplasmic transport vesicles in the neurites of hippocampal neurons. {ECO:0000250}. |
Tissue Specificity | Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas. {ECO:0000269|PubMed:10762626, ECO:0000269|PubMed:11526494, ECO:0000269|PubMed:12888911}. |
KIF1B CRISPR/Cas9 KO Plasmid (h) - sc-403727 from Santa Cruz Biotechnology
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KIF1B HDR Plasmid (h) - sc-403727-HDR from Santa Cruz Biotechnology
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KIF1B Double Nickase Plasmid (h) - sc-403727-NIC from Santa Cruz Biotechnology
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KIF1B Double Nickase Plasmid (h2) - sc-403727-NIC-2 from Santa Cruz Biotechnology
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KIF1B CRISPR Activation Plasmid (h) - sc-403727-ACT from Santa Cruz Biotechnology
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KIF1B CRISPR Activation Plasmid (h2) - sc-403727-ACT-2 from Santa Cruz Biotechnology
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KIF1B Lentiviral Activation Particles (h) - sc-403727-LAC from Santa Cruz Biotechnology
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KIF1B Lentiviral Activation Particles (h2) - sc-403727-LAC-2 from Santa Cruz Biotechnology
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KIF1B siRNA (h) - sc-35749 from Santa Cruz Biotechnology
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KIF1B shRNA Plasmid (h) - sc-35749-SH from Santa Cruz Biotechnology
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KIF1B shRNA (h) Lentiviral Particles - sc-35749-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU079471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11183 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11183 from Sigma-Aldrich
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KIF1B siRNA (Human) - CRH7994 from Cohesion Biosciences
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KIF1B RNAi - H00023095-R02 from Novus Biologicals
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KIF1B RNAi - H00023095-R01 from Novus Biologicals
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shRNA set against Human KIF1B (NM_183416.3) - SHH325099 from Creative biogene
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Human KIF1B siRNA - orb268496 from Biorbyt
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KIF1B shRNA Plasmid (Human) - CHH7994 from Cohesion Biosciences
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