| Gene Symbol | RAB11B |
|---|---|
| Entrez Gene | 9230 |
| Alt Symbol | H-YPT3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAB11B, member RAS oncogene family |
| Other Description | GTP-binding protein YPT3|RAB11B, member of RAS oncogene family|ras-related protein Rab-11B |
| Swissprots | Q2YDT2 Q8NI07 Q15907 Q6FHR0 B2R7I4 Q6FI42 B4DMK0 Q5U0I1 A5YM50 D6W671 |
| Accessions | EAW68925 EAW68926 EAW68927 Q15907 AF498947 AAM21095 AK225036 AK225642 AK297498 BAG59912 AK310573 AK312994 BAG35831 BC110081 AAI10082 BP367041 BP396219 BT019535 AAV38342 BT019536 AAV38343 BX647356 CR536494 CAG38733 CR541691 CAG46492 CX787570 D38516 EF560724 ABQ59034 GQ129215 ACT64349 GQ129216 ACT64350 X79780 CAA56176 NM_004218 NP_004209 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage- gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:14627637, ECO:0000269|PubMed:19029296, ECO:0000269|PubMed:19244346, ECO:0 |
| Subcellular Location | Recycling endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305|PubMed:21255211}; Lipid-anchor {ECO:0000305|PubMed:21255211}; Cytoplasmic side {ECO:0000305|PubMed:21255211}. Note=Recruited to phagosomes containing S.aureus. |
| Top Pathways | Endocytosis, Vasopressin-regulated water reabsorption, AMPK signaling pathway |