| Gene Symbol |
CCDC88A
|
| Entrez Gene |
55704
|
| Alt Symbol |
APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coiled-coil domain containing 88A
|
| Other Description |
AKT-phosphorylation enhancer|Hook-related protein 1|g alpha-interacting vesicle-associated protein|girders of actin filament|girders of actin filaments|girdin
|
| Swissprots |
Q7Z3C5 Q5HYD0 B7ZM78 Q53SF1 Q581G3 A1IGE7 Q3V6T2 C9JG83 Q7Z339
|
| Accessions |
AAX82029 AAY14932 EAX00099 EAX00100 EAX00101 Q3V6T2 AB033038 BAA86526 AB125644 BAF44475 AB201172 BAE44387 AF112218 AAF17206 AK001254 BAA91584 AK024717 AK025723 AK124603 BAG54056 AK124761 AK299823 BAG61692 AK307964 AL036590 AV728179 BC014905 BC015539 BC032683 BC035848 BC041160 AAH41160 BC045829 BC056885 BC060037 AAH60037 BC078168 AAH78168 BC092515 BC132736 AAI32737 BC142646 BC142700 BC144320 AAI44321 BU570532 BX537985 CAD97945 BX538154 CAD98038 BX647874 BX648138 CAI46020 D64159 BAA21515 DA488073 XM_005264418 XP_005264475 XM_005264421 XP_005264478 XM_005264426 XP_005264483 XM_011532964 XP_011531266 XM_011532965 XP_011531267 XM_011532966 XP_011531268 XM_011532967 XP_011531269 XM_011532968 XP_011531270 XM_011532969 XP_011531271 NM_001135597 NP_001129069 NM_001254943 NP_001241872 NM_018084 NP_060554
|
| Function |
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. {ECO:0000250, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cell membrane {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cytoplasm, cytosol. Cytoplasmic vesicle {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides. {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}.
|
| Tissue Specificity |
Expressed ubiquitously. {ECO:0000269|PubMed:16139227}.
|