CCDC88A

Gene Symbol CCDC88A
Entrez Gene 55704
Alt Symbol APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212
Species Human
Gene Type protein-coding
Description coiled-coil domain containing 88A
Other Description AKT-phosphorylation enhancer|Hook-related protein 1|g alpha-interacting vesicle-associated protein|girders of actin filament|girders of actin filaments|girdin
Swissprots Q7Z3C5 Q5HYD0 B7ZM78 Q53SF1 Q581G3 A1IGE7 Q3V6T2 C9JG83 Q7Z339
Accessions AAX82029 AAY14932 EAX00099 EAX00100 EAX00101 Q3V6T2 AB033038 BAA86526 AB125644 BAF44475 AB201172 BAE44387 AF112218 AAF17206 AK001254 BAA91584 AK024717 AK025723 AK124603 BAG54056 AK124761 AK299823 BAG61692 AK307964 AL036590 AV728179 BC014905 BC015539 BC032683 BC035848 BC041160 AAH41160 BC045829 BC056885 BC060037 AAH60037 BC078168 AAH78168 BC092515 BC132736 AAI32737 BC142646 BC142700 BC144320 AAI44321 BU570532 BX537985 CAD97945 BX538154 CAD98038 BX647874 BX648138 CAI46020 D64159 BAA21515 DA488073 XM_005264418 XP_005264475 XM_005264421 XP_005264478 XM_005264426 XP_005264483 XM_011532964 XP_011531266 XM_011532965 XP_011531267 XM_011532966 XP_011531268 XM_011532967 XP_011531269 XM_011532968 XP_011531270 XM_011532969 XP_011531271 NM_001135597 NP_001129069 NM_001254943 NP_001241872 NM_018084 NP_060554
Function Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. {ECO:0000250, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}.
Subcellular Location Membrane {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cell membrane {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cytoplasm, cytosol. Cytoplasmic vesicle {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides. {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}.
Tissue Specificity Expressed ubiquitously. {ECO:0000269|PubMed:16139227}.

Girdin Antibody - 14200 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from RD and A-375 cells using Girdin Antibody.

girdin (H-127) - sc-292900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
girdin (H-127): sc-292900. Western blot analysis of girdin expression in HeLa whole cell lysate.

girdin (H-6) - sc-393757 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
girdin (H-6): sc-393757. Western blot analysis of girdin expression in NIH/3T3 whole cell lysate.

girdin (T-13) - sc-133371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
girdin (T-13): sc-133371. Western blot analysis of girdin expression in HeLa (A) and NIH/3T3 (B) whole cell lysates.

Anti-Girdin (phospho S1417) antibody - ab111440 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111440, at 1/50 dilution, staining Girdin in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-Girdin antibody - ab113890 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab113890, at 5 µg/ml, staining Girdin in Formalin-Fixed, Paraffin-Embedded Human tonsil tissue by immunohistochemistry.

Anti-Girdin antibody - ab111035 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111035, at a 1/50 dilution, staining Girdin in paraffin embedded Human brain tissue by Immunohistochemistry. Image on the right was from tissues treated with the synthetic peptide.

Anti-Girdin antibody - ab113282 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Girdin by Western Blot of Immunprecipitate. An antibody to Girdin at 1µg/ml staining Girdin in HeLa whole cell lysate immunoprecipitated using ab113282 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-CCDC88A / GIV / Girdin Antibody - LS-C193976 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCDC88A / GIV / Girdin Antibody - LS-C193977 from LifeSpan Bioscience

Prices $1,035.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCDC88A / GIV / Girdin Antibody (aa1383-1432) - LS-C118360 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using Girdin (Ab-1417) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-CCDC88A / GIV / Girdin Antibody (aa1425-1475) - LS-C289803 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC88A / GIV / Girdin Antibody (aa425-475) - LS-C289801 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC88A / GIV / Girdin Antibody (phospho-Ser1417) - LS-C198999 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma, using Girdin (Phospho-Ser1417) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-CCDC88A / GIV / Girdin Antibody (C-Terminus) IHC-plus™ - LS-B5063 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Girdin antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5063 concentration 5 ug/ml.

APE Antibody (200913) - MAB1044 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 200913

APE Antibody [Unconjugated] - AF1044 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, Balb/3T3 mouse embryonic fibroblast cell line, and Rat-2 rat embryonic fibroblast cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat APE Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1044) followed by HRP‑conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for APE at approximately 40 kDa (as indicated). This experiment was conducted using Immunoblot Buffer Group 1.

Girdin Antibody - AF5345 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
Western Blot Girdin Antibody

Girdin Antibody - NBP1-76253 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Girdin Antibody [NBP1-76253] - Rat brain tissue lysate with Girdin antibody at (A) 1 and (B) 2 ug/mL.

Girdin Antibody - NBP1-71857 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Girdin Antibody [NBP1-71857] - Whole cell lysate (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Affinity purified rabbit anti-CCDC88A antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. CCDC88A was also immunoprecipitated by rabbit anti-CCDC88A antibody NBP1-71856 , which recognizes an upstream epitope

Girdin Antibody - NBP1-71856 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Girdin Antibody [NBP1-71856] - Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. : Affinity purified rabbit anti-CCDC88A antibody used for IP at 6 mcg/mg lysate. CCDC88A was also immunoprecipitated by rabbit anti-CCDC88A antibody NBP1-71857, which recognizes a downstream epitope.

Girdin Antibody - NBP2-38387 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Girdin Antibody [NBP2-38387] - Staining of human appendix shows leukocyte positivity in Germinal center.

Girdin Antibody [Biotin] - BAF5345 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of A431 human epithelial carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Girdin Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF5345) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Girdin at approximately XXX kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group XXX.

Girdin (Tyr1765) Polyclonal Antibody - bs-13358R from Bioss

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded human colon cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-Girdin (Tyr1765) Polyclonal Antibody, Unconjugated (bs-13358R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 90 minutes and DAB staining.

Girdin (Ser1417) Polyclonal Antibody - bs-6465R from Bioss

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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