CCDC88A

Gene Symbol CCDC88A
Entrez Gene 55704
Alt Symbol APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212
Species Human
Gene Type protein-coding
Description coiled-coil domain containing 88A
Other Description AKT-phosphorylation enhancer|Hook-related protein 1|g alpha-interacting vesicle-associated protein|girders of actin filament|girders of actin filaments|girdin
Swissprots Q7Z3C5 Q5HYD0 B7ZM78 Q53SF1 Q581G3 A1IGE7 Q3V6T2 C9JG83 Q7Z339
Accessions AAX82029 AAY14932 EAX00099 EAX00100 EAX00101 Q3V6T2 AB033038 BAA86526 AB125644 BAF44475 AB201172 BAE44387 AF112218 AAF17206 AK001254 BAA91584 AK024717 AK025723 AK124603 BAG54056 AK124761 AK299823 BAG61692 AK307964 AL036590 AV728179 BC014905 BC015539 BC032683 BC035848 BC041160 AAH41160 BC045829 BC056885 BC060037 AAH60037 BC078168 AAH78168 BC092515 BC132736 AAI32737 BC142646 BC142700 BC144320 AAI44321 BU570532 BX537985 CAD97945 BX538154 CAD98038 BX647874 BX648138 CAI46020 D64159 BAA21515 DA488073 XM_005264418 XP_005264475 XM_005264421 XP_005264478 XM_005264426 XP_005264483 XM_011532964 XP_011531266 XM_011532965 XP_011531267 XM_011532966 XP_011531268 XM_011532967 XP_011531269 XM_011532968 XP_011531270 XM_011532969 XP_011531271 NM_001135597 NP_001129069 NM_001254943 NP_001241872 NM_018084 NP_060554
Function Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. {ECO:0000250, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}.
Subcellular Location Membrane {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cell membrane {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cytoplasm, cytosol. Cytoplasmic vesicle {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides. {ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227}.
Tissue Specificity Expressed ubiquitously. {ECO:0000269|PubMed:16139227}.

girdin CRISPR/Cas9 KO Plasmid (h) - sc-402236 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

girdin HDR Plasmid (h) - sc-402236-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

girdin Double Nickase Plasmid (h) - sc-402236-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

girdin Double Nickase Plasmid (h2) - sc-402236-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

girdin CRISPR Activation Plasmid (h) - sc-402236-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

girdin CRISPR Activation Plasmid (h2) - sc-402236-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

girdin Lentiviral Activation Particles (h) - sc-402236-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

girdin Lentiviral Activation Particles (h2) - sc-402236-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

girdin siRNA (h) - sc-94984 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

girdin shRNA Plasmid (h) - sc-94984-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

girdin shRNA (h) Lentiviral Particles - sc-94984-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU098851 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU095281 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5578 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5578 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CCDC88A siRNA (Human) - CRJ0848 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCDC88A - MBS8226971 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Ccdc88a (NM_018084.4) - SHH257253 from Creative biogene

Category siRNA
Species Reactivities Human

Human CCDC88A siRNA - orb271349 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCDC88A shRNA Plasmid (Human) - CHJ0848 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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