| Gene Symbol |
SLC5A11
|
| Entrez Gene |
115584
|
| Alt Symbol |
KST1, RKST1, SGLT6, SMIT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 5 (sodium/inositol cotransporter), member 11
|
| Other Description |
Na(+)/myo-inositol cotransporter 2|homolog of rabbit KST1|putative sodium-coupled cotransporter RKST1|sodium-dependent glucose cotransporter|sodium/glucose cotransporter KST1|sodium/myo-inositol cotransporter 2|sodium/myo-inositol transporter 2|solute carrier family 5 (sodium/glucose cotransporter), member 11
|
| Swissprots |
Q6PF02 B7Z329 Q96PP5 Q86Y55 Q6ZUW3 Q05BF1 Q8WWX8
|
| Accessions |
EAW55781 Q8WWX8 AA772233 AF292385 AAK97053 AJ305237 CAC83728 AK125267 BAC86105 AK295427 BAH12065 AK298373 BAH12770 AK303691 BAH14019 AY044906 AAK97784 BC049385 AAH49385 BC057780 AAH57780 DC332171 U41898 AAB61733 XM_005255080 XP_005255137 XM_005255082 XP_005255139 XM_006721015 XP_006721078 XM_011545723 XP_011544025 XM_011545724 XP_011544026 XM_011545725 XP_011544027 XM_011545726 XP_011544028 XM_011545727 XP_011544029 XM_011545728 XP_011544030 NM_001258411 NP_001245340 NM_001258412 NP_001245341 NM_001258413 NP_001245342 NM_001258414 NP_001245343 NM_052944 NP_443176
|
| Function |
Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. {ECO:0000269|PubMed:15172003}.
|
| Subcellular Location |
Membrane {ECO:0000250|UniProtKB:Q28728}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q28728}.
|
| Tissue Specificity |
Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:12039040}.
|
![Western Blot: SLC5A11 Overexpression Lysate (Adult Normal) [NBP2-05835] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC5A11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10104_SLC5A11%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05835-img0001.jpg)