SLC5A11

Gene Symbol SLC5A11
Entrez Gene 115584
Alt Symbol KST1, RKST1, SGLT6, SMIT2
Species Human
Gene Type protein-coding
Description solute carrier family 5 (sodium/inositol cotransporter), member 11
Other Description Na(+)/myo-inositol cotransporter 2|homolog of rabbit KST1|putative sodium-coupled cotransporter RKST1|sodium-dependent glucose cotransporter|sodium/glucose cotransporter KST1|sodium/myo-inositol cotransporter 2|sodium/myo-inositol transporter 2|solute carrier family 5 (sodium/glucose cotransporter), member 11
Swissprots Q6PF02 B7Z329 Q96PP5 Q86Y55 Q6ZUW3 Q05BF1 Q8WWX8
Accessions EAW55781 Q8WWX8 AA772233 AF292385 AAK97053 AJ305237 CAC83728 AK125267 BAC86105 AK295427 BAH12065 AK298373 BAH12770 AK303691 BAH14019 AY044906 AAK97784 BC049385 AAH49385 BC057780 AAH57780 DC332171 U41898 AAB61733 XM_005255080 XP_005255137 XM_005255082 XP_005255139 XM_006721015 XP_006721078 XM_011545723 XP_011544025 XM_011545724 XP_011544026 XM_011545725 XP_011544027 XM_011545726 XP_011544028 XM_011545727 XP_011544029 XM_011545728 XP_011544030 NM_001258411 NP_001245340 NM_001258412 NP_001245341 NM_001258413 NP_001245342 NM_001258414 NP_001245343 NM_052944 NP_443176
Function Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. {ECO:0000269|PubMed:15172003}.
Subcellular Location Membrane {ECO:0000250|UniProtKB:Q28728}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q28728}.
Tissue Specificity Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:12039040}.

SLC5A11 Overexpression Lysate (Native) - NBP2-05835 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: SLC5A11 Overexpression Lysate (Adult Normal) [NBP2-05835] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC5A11.

Panoply™ Human SLC5A11 Knockdown Stable Cell Line - CSC-DC014613 from Creative biogene

Category Cell Line
Species Human
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