Gene Symbol | PACS2 |
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Entrez Gene | 23241 |
Alt Symbol | PACS-2, PACS1L |
Species | Human |
Gene Type | protein-coding |
Description | phosphofurin acidic cluster sorting protein 2 |
Other Description | PACS1-like protein |
Swissprots | Q96FL7 A2VDJ9 Q6P191 O60342 G8JLK3 Q86VP3 |
Accessions | EAW81915 Q86VP3 AB011174 BAA25528 AB029326 BAB87116 AB072449 BAB88325 AK098354 BAC05290 AL539052 AY320284 AAQ83882 BC010663 AAH10663 BC028418 BC050351 AAH50351 BC065220 AAH65220 BC095493 BC131591 AAI31592 BU944012 CA423467 DA177001 DA275449 DA408379 DA491365 HY009105 XM_005267462 XP_005267519 XM_005267463 XP_005267520 XM_006720085 XP_006720148 XM_006720086 XP_006720149 XM_006720087 XP_006720150 XM_006720088 XP_006720151 XM_006720089 XP_006720152 XM_006720090 XP_006720153 XM_006720091 XP_006720154 XM_006720092 XP_006720155 XM_011536585 XP_011534887 NM_001100913 NP_001094383 NM_001243127 NP_001230056 NM_015197 NP_056012 |
Function | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000269|PubMed:15692567}. Mitochondrion {ECO:0000269|PubMed:15692567}. |
Tissue Specificity | Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis. {ECO:0000269|PubMed:15692567}. |
PACS-2 (Q-20) - sc-160645 from Santa Cruz Biotechnology
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PACS-2 (E-17) - sc-160643 from Santa Cruz Biotechnology
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Anti-PACS2 antibody - ab129402 from Abcam
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Anti-PACS2 antibody - ab121136 from Abcam
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Anti-PACS2 Antibody (aa641-671, AP) - LS-C265441 from LifeSpan Bioscience
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Anti-PACS2 Antibody (aa641-671, Biotin) - LS-C265442 from LifeSpan Bioscience
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Anti-PACS2 Antibody (aa641-671, APC) - LS-C265443 from LifeSpan Bioscience
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Anti-PACS2 Antibody (aa641-671, FITC) - LS-C265444 from LifeSpan Bioscience
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Anti-PACS2 Antibody (aa641-671, PE) - LS-C265445 from LifeSpan Bioscience
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Anti-PACS2 Antibody (aa641-671, Azide-free, HRP) - LS-C265446 from LifeSpan Bioscience
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Anti-PACS2 Antibody (Internal) IHC-plus⢠- LS-B12223 from LifeSpan Bioscience
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Anti-PACS2 Antibody (aa642-671) - LS-C163335 from LifeSpan Bioscience
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PACS2 Antibody - NBP1-81496 from Novus Biologicals
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Anti-PACS2 antibody produced in rabbit - SAB2105784 from Sigma-Aldrich
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Anti-PACS2 antibody produced in rabbit - HPA001423 from Sigma-Aldrich
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PACS2 antibody - middle region (ARP51659_P050) - ARP51659_P050 from Aviva Systems Biology
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PACS2-Antibody-C-term - AP13142b from Abgent, a WuXi AppTec company
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PACS2 antibody - GTX110869 from GeneTex
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PACS2 Antibody - C-terminal region (OAAB09441) - OAAB09441 from Aviva Systems Biology
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Phosphofurin Acidic Cluster Sorting Protein 2 Antibody - abx114462 from Abbexa
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PACS2 antibody - 19508-1-AP from Acris Antibodies
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PACS2 Antibody - 8189 from ProSci
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PACS2-Specific antibody - 19508-1-AP from Proteintech Group
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PACS2, Polyclonal Antibody - MBS153374 from MyBioSource
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PACS2 Antibody - GWB-MS262A from Genway Biotech
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