PACS2

Gene Symbol PACS2
Entrez Gene 23241
Alt Symbol PACS-2, PACS1L
Species Human
Gene Type protein-coding
Description phosphofurin acidic cluster sorting protein 2
Other Description PACS1-like protein
Swissprots Q96FL7 A2VDJ9 Q6P191 O60342 G8JLK3 Q86VP3
Accessions EAW81915 Q86VP3 AB011174 BAA25528 AB029326 BAB87116 AB072449 BAB88325 AK098354 BAC05290 AL539052 AY320284 AAQ83882 BC010663 AAH10663 BC028418 BC050351 AAH50351 BC065220 AAH65220 BC095493 BC131591 AAI31592 BU944012 CA423467 DA177001 DA275449 DA408379 DA491365 HY009105 XM_005267462 XP_005267519 XM_005267463 XP_005267520 XM_006720085 XP_006720148 XM_006720086 XP_006720149 XM_006720087 XP_006720150 XM_006720088 XP_006720151 XM_006720089 XP_006720152 XM_006720090 XP_006720153 XM_006720091 XP_006720154 XM_006720092 XP_006720155 XM_011536585 XP_011534887 NM_001100913 NP_001094383 NM_001243127 NP_001230056 NM_015197 NP_056012
Function Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}.
Subcellular Location Endoplasmic reticulum lumen {ECO:0000269|PubMed:15692567}. Mitochondrion {ECO:0000269|PubMed:15692567}.
Tissue Specificity Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis. {ECO:0000269|PubMed:15692567}.

PACS-2 CRISPR/Cas9 KO Plasmid (h) - sc-403026 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACS-2 HDR Plasmid (h) - sc-403026-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACS-2 Double Nickase Plasmid (h) - sc-403026-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACS-2 Double Nickase Plasmid (h2) - sc-403026-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACS-2 CRISPR Activation Plasmid (h) - sc-403026-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACS-2 CRISPR Activation Plasmid (h2) - sc-403026-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACS-2 Lentiviral Activation Particles (h) - sc-403026-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACS-2 Lentiviral Activation Particles (h2) - sc-403026-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACS-2 siRNA (h) - sc-92426 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACS-2 shRNA Plasmid (h) - sc-92426-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACS-2 shRNA (h) Lentiviral Particles - sc-92426-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU136321 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16260 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16260 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PACS2 siRNA (Human) - CRH8115 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PACS2 (NM_015197.3) - SHH369880 from Creative biogene

Category siRNA
Species Reactivities Human

Human PACS2 siRNA - orb268617 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PACS2 shRNA Plasmid (Human) - CHH8115 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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