Gene Symbol | Dkk3 |
---|---|
Entrez Gene | 50781 |
Alt Symbol | AW061014, C87148 |
Species | Mouse |
Gene Type | protein-coding |
Description | dickkopf homolog 3 (Xenopus laevis) |
Other Description | dickkopf-3|dickkopf-related protein 3|dkk-3|mDkk-3 |
Swissprots | Q9QUN9 |
Accessions | EDL17021 EDL17022 EDL17023 EDL17024 Q9QUN9 AF177400 AAF02680 AJ243964 CAB60111 AK004853 BAB23617 AK013054 AK013622 AK191518 AK192759 AK199048 AK207247 AK208577 AK209927 BC005519 BC046304 AAH46304 BC050934 AAH50934 XM_006508013 XP_006508076 XM_006508014 XP_006508077 NM_015814 NP_056629 |
Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted. |
Tissue Specificity | Highest expression in brain, eye and heart. |
Anti-Dkk3 antibody [9E12] - ab196532 from Abcam
|
||||||||||
Dkk-3 Antibody - AF948 from Novus Biologicals
|
||||||||||
Dkk-3 Antibody (153103) - MAB948-050 from Novus Biologicals
|
||||||||||
Dkk-3 Antibody - NBP1-45522 from Novus Biologicals
|
||||||||||
Dkk-3 Antibody (RM0221-9E12) - NBP2-12265 from Novus Biologicals
|
||||||||||
Dkk-3 Antibody [Biotin] - BAF948 from Novus Biologicals
|
||||||||||
DKK3 antibody [9E12] - GTX53312 from GeneTex
|
||||||||||
DKK3 antibody - 70R-12170 from Fitzgerald
|
||||||||||
Anti -DKK3 (Dickkopf Homolog 3, Dkk-3) - 216456 from USBiological Life Science
|
||||||||||
DKK3 antibody - 20R-1753 from Fitzgerald
|
||||||||||
Dickkopf Homolog 3 (Xenopus Laevis) Antibody - abx112065 from Abbexa
|
||||||||||
Dickkopf-3 (DKK3) antibody - PAB8678 from Acris Antibodies
|
||||||||||
Rabbit Anti-DKK3 Antibody - 168-10685 from RayBiotech
|
||||||||||
Dkk-3, Monoclonal Antibody - MBS690525 from MyBioSource
|
||||||||||
DKK-3 / Dkk3 / Dickkopf-3 Antibody, Rabbit PAb - 50247-RP01-100 from Sino Biological
|
||||||||||
DKK-3 / Dkk3 / Dickkopf-3 Antibody, Rabbit PAb, Antigen Affinity Purified - 50247-RP02-50 from Sino Biological
|
||||||||||
DKK3 Antibody, Rabbit MAb - 50247-R019-50 from Sino Biological
|
||||||||||
DKK3 Antibody - CSB-PA006922GA01HU from Cusabio
|
||||||||||
DKK3, Polyclonal Antibody - MBS840225 from MyBioSource
|
||||||||||
DKK3-Antibody - ABV10690 from Abgent, a WuXi AppTec company
|
||||||||||
Dickkopf 3 antibody - orb42400 from Biorbyt
|
||||||||||
Dickkopf 3 antibody - orb170233 from Biorbyt
|
||||||||||
DKK3 Antibody - CSB-PA865568XA01MO from Cusabio
|