Gene Symbol | Dkk3 |
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Entrez Gene | 50781 |
Alt Symbol | AW061014, C87148 |
Species | Mouse |
Gene Type | protein-coding |
Description | dickkopf homolog 3 (Xenopus laevis) |
Other Description | dickkopf-3|dickkopf-related protein 3|dkk-3|mDkk-3 |
Swissprots | Q9QUN9 |
Accessions | EDL17021 EDL17022 EDL17023 EDL17024 Q9QUN9 AF177400 AAF02680 AJ243964 CAB60111 AK004853 BAB23617 AK013054 AK013622 AK191518 AK192759 AK199048 AK207247 AK208577 AK209927 BC005519 BC046304 AAH46304 BC050934 AAH50934 XM_006508013 XP_006508076 XM_006508014 XP_006508077 NM_015814 NP_056629 |
Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted. |
Tissue Specificity | Highest expression in brain, eye and heart. |
Dkk-3 CRISPR/Cas9 KO Plasmid (m) - sc-424494 from Santa Cruz Biotechnology
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Dkk-3 HDR Plasmid (m) - sc-424494-HDR from Santa Cruz Biotechnology
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Dkk-3 Double Nickase Plasmid (m) - sc-424494-NIC from Santa Cruz Biotechnology
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Dkk-3 Double Nickase Plasmid (m2) - sc-424494-NIC-2 from Santa Cruz Biotechnology
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Dkk-3 CRISPR Activation Plasmid (m) - sc-424494-ACT from Santa Cruz Biotechnology
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Dkk-3 CRISPR Activation Plasmid (m2) - sc-424494-ACT-2 from Santa Cruz Biotechnology
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Dkk-3 Lentiviral Activation Particles (m) - sc-424494-LAC from Santa Cruz Biotechnology
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Dkk-3 Lentiviral Activation Particles (m2) - sc-424494-LAC-2 from Santa Cruz Biotechnology
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Dkk-3 siRNA (m) - sc-41103 from Santa Cruz Biotechnology
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Dkk-3 shRNA Plasmid (m) - sc-41103-SH from Santa Cruz Biotechnology
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Dkk-3 shRNA (m) Lentiviral Particles - sc-41103-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU012251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30017 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30017 from Sigma-Aldrich
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DKK3 siRNA (Mouse) - CRM5147 from Cohesion Biosciences
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DKK3 - MBS8214047 from MyBioSource
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shRNA set against Mouse DKK3 (NM_015814.2) - SHH278369 from Creative biogene
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shRNA set against Mouse Dkk3(NM_015814.2) - SHH006203 from Creative biogene
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Mouse DKK3 siRNA - orb284623 from Biorbyt
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DKK3 shRNA Plasmid (Mouse) - CHM5147 from Cohesion Biosciences
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