| Gene Symbol |
Dkk3
|
| Entrez Gene |
50781
|
| Alt Symbol |
AW061014, C87148
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
dickkopf homolog 3 (Xenopus laevis)
|
| Other Description |
dickkopf-3|dickkopf-related protein 3|dkk-3|mDkk-3
|
| Swissprots |
Q9QUN9
|
| Accessions |
EDL17021 EDL17022 EDL17023 EDL17024 Q9QUN9 AF177400 AAF02680 AJ243964 CAB60111 AK004853 BAB23617 AK013054 AK013622 AK191518 AK192759 AK199048 AK207247 AK208577 AK209927 BC005519 BC046304 AAH46304 BC050934 AAH50934 XM_006508013 XP_006508076 XM_006508014 XP_006508077 NM_015814 NP_056629
|
| Function |
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Highest expression in brain, eye and heart.
|