TNKS2

Gene Symbol TNKS2
Entrez Gene 80351
Alt Symbol ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6
Species Human
Gene Type protein-coding
Description tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Other Description ADP-ribosyltransferase diphtheria toxin-like 6|TNKS-2|TRF1-interacting ankyrin-related ADP-ribose polymerase 2|poly [ADP-ribose] polymerase 5B|tankyrase 2|tankyrase II|tankyrase-2|tankyrase-like protein|tankyrase-related protein
Swissprots B2RBD3 Q9H2K2 Q9HAS4 Q9H8F2
Accessions EAW50105 Q9H2K2 AF264912 AAG44694 AF305081 AAG25674 AF309033 AAK82330 AF329696 AAK13463 AF342982 AAK25811 AF438201 AAL40795 AK023746 BAB14665 AK314612 BAG37180 AL833676 BC023218 BC148498 AAI48499 BC156931 AAI56932 BQ019749 XM_005270185 XP_005270242 XM_011540213 XP_011538515 XM_011540214 XP_011538516 XM_011540215 XP_011538517 NM_025235 NP_079511
Function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245}.
Subcellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
Tissue Specificity Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.

Tankyrase-2 (N-16) - sc-22854 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Tankyrase-2 (S-17) - sc-22855 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tankyrase-2 (S-17): sc-22855. Immunoperoxidase staining of formalin fixed, paraffin-embedded human epididymis tissue showing nuclear and cytoplasmic staining of glandular cells.

Anti-Tankyrase 2 antibody - ab103781 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Tankyrase 2 antibody (ab103781) at 1/50 dilution + Mouse testis lysate at 35 µg

Anti-Tankyrase 2 antibody - N-terminal - ab155545 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Tankyrase 2 antibody - N-terminal (ab155545) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : HeLa whole cell lysateLane 3 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-TANK2 / TNKS2 Antibody - LS-C18032 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody - LS-C18031 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody (aa800-900) - LS-C112767 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody (aa1126-1156, APC) - LS-C241977 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody (aa1126-1156, Biotin) - LS-C241978 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody (aa1126-1156, AP) - LS-C241976 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody (aa1126-1156, FITC) - LS-C241979 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody (aa1126-1156, PE) - LS-C241980 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody (aa1134-1164) - LS-C325847 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody (aa1126-1156, Azide-free, HRP) - LS-C247102 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody - LS-C178468 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TANK2 / TNKS2 Antibody (aa1126-1156) - LS-C160089 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Tnks 2 Antibody western blot of mouse testis tissue lysates (35 ug/lane). The Tnks 2 antibody detected Tnks 2 protein (arrow).

Anti-TANK2 / TNKS2 Antibody - LS-C178473 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TNKS2 Antibody - NBP2-20675 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TNKS2 Antibody [NBP2-20675] - Sample (30 ug of whole cell lysate) A: A431 B: Hela C: Hep G2 7.5% SDS PAGE GTX104638 diluted at 1:1000.

TNKS2 Antibody - NBP1-28497 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: TNKS2 Antibody [NBP1-28497] - (0.5ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Tankyrase 1 Antibody - NBP1-80947 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TNKS2 Antibody - NBP1-80946 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: TNKS2 Antibody [NBP1-80946] - Staining of human kidney shows strong cytoplasmic positivity in subset of cells in tubules.

TNKS2 Antibody - NBP1-36993 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TNKS2 antibody produced in goat - SAB2501125 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TNKS2: <B>Cat. No. SAB2501125</B>: HEK293 overexpressing TANK2 (Lane 4) and TANK1 (Lane 2) and probed with Cat. No. SAB2501125 (mock transfection in first lane). Lane 3 is empty. Lower panel shows the same lysates probed for α-Actin to show protein levels. Primary incubation (0.5 μg/mL) was overnight at 4 °C. Detected by chemiluminescence.

Anti-TNKS2 antibody produced in goat - SAB2501174 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TNKS2: <B>Cat. No. SAB2501174</B>: (0.5 μg/mL) staining of Jurkat lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

ANTI-TNKS 2(C-TERMINAL) antibody produced in rabbit - SAB1306137 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-Tnks 2 (C-term): <B>Cat. No. SAB1306137</B>: Tnks 2 Antibody (C-term) western blot analysis in Mouse testis tissue lysates (35 μg/lane).
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