| Gene Symbol |
TNKS2
|
| Entrez Gene |
80351
|
| Alt Symbol |
ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
|
| Other Description |
ADP-ribosyltransferase diphtheria toxin-like 6|TNKS-2|TRF1-interacting ankyrin-related ADP-ribose polymerase 2|poly [ADP-ribose] polymerase 5B|tankyrase 2|tankyrase II|tankyrase-2|tankyrase-like protein|tankyrase-related protein
|
| Swissprots |
B2RBD3 Q9H2K2 Q9HAS4 Q9H8F2
|
| Accessions |
EAW50105 Q9H2K2 AF264912 AAG44694 AF305081 AAG25674 AF309033 AAK82330 AF329696 AAK13463 AF342982 AAK25811 AF438201 AAL40795 AK023746 BAB14665 AK314612 BAG37180 AL833676 BC023218 BC148498 AAI48499 BC156931 AAI56932 BQ019749 XM_005270185 XP_005270242 XM_011540213 XP_011538515 XM_011540214 XP_011538516 XM_011540215 XP_011538517 NM_025235 NP_079511
|
| Function |
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245}.
|
| Subcellular Location |
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
|
| Tissue Specificity |
Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
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