TNKS2

Gene Symbol	TNKS2
Entrez Gene	80351
Alt Symbol	ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6
Species	Human
Gene Type	protein-coding
Description	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Other Description	ADP-ribosyltransferase diphtheria toxin-like 6|TNKS-2|TRF1-interacting ankyrin-related ADP-ribose polymerase 2|poly [ADP-ribose] polymerase 5B|tankyrase 2|tankyrase II|tankyrase-2|tankyrase-like protein|tankyrase-related protein
Swissprots	B2RBD3 Q9H2K2 Q9HAS4 Q9H8F2
Accessions	EAW50105 Q9H2K2 AF264912 AAG44694 AF305081 AAG25674 AF309033 AAK82330 AF329696 AAK13463 AF342982 AAK25811 AF438201 AAL40795 AK023746 BAB14665 AK314612 BAG37180 AL833676 BC023218 BC148498 AAI48499 BC156931 AAI56932 BQ019749 XM_005270185 XP_005270242 XM_011540213 XP_011538515 XM_011540214 XP_011538516 XM_011540215 XP_011538517 NM_025235 NP_079511
Function	Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245}.
Subcellular Location	Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
Tissue Specificity	Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Tankyrase 2, TNKS2, Human, ELISA Kit - E-EL-H2419 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Tankyrase 2, TNKS2, Rabbit, ELISA Kit - E-EL-RB2227 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Tankyrase 2, TNKS2, Chicken, ELISA Kit - E-EL-Ch1919 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Tankyrase 2, TNKS2, Porcine, ELISA Kit - E-EL-P0822 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Tankyrase 2, TNKS2, Monkey, ELISA Kit - E-EL-MK1184 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human TNKS2(Tankyrase 2) ELISA Kit - E-EL-H2419 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human TNKS2 (Tankyrase 2) CLIA Kit - E-CL-H1421 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

Tankyrase 2 (TNKS2), ELISA Kit - MBS9308820 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TNKS2, ELISA Kit - MBS2507112 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

TNKS2, ELISA Kit - MBS2506875 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

TNKS2, ELISA Kit - MBS2511778 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

TNKS2, ELISA Kit - MBS2505638 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

TNKS2, ELISA Kit - MBS2504105 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

Human TNKS2(Tankyrase 2) ELISA Kit - E-EL-H2419 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human TNKS2 (Tankyrase 2) CLIA Kit - E-CL-H1421 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Human Tankyrase 2 ELISA Kit - abx253288 from Abbexa Category ELISA Kit Sensitivity 0.094 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human TANK2 / TNKS2 ELISA Kit (Sandwich ELISA) - LS-F21263 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

Tankyrase 2 (TNKS2), Human, ELISA Kit - DL-TNKS2-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

TNKS2 (Tankyrase 2), CLIA Kit - MBS2533156 from MyBioSource Category CLIA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

Human TNKS2 ELISA Kit - abx570640 from Abbexa Category ELISA Kit Sensitivity 0.04 ng/ml Range 0.156 ng/ml - 10 ng/ml

TNKS2 - EKH7778 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156--10ng/ml

Human TNKS2 ELISA Kit - E037453 from Biobool Category ELISA Kit Sensitivity <0.094ng/ml

anti-Tankyrase 2 antibody - ARG64706 from Arigo Biolaboratories Category ELISA Kit

anti-TANK2 antibody - ARG64774 from Arigo Biolaboratories Category ELISA Kit

Human Tankyrase-2 (TNKS2) ELISA Kit - AE13942HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t

Search more