| Gene Symbol |
LRRC7
|
| Entrez Gene |
57554
|
| Alt Symbol |
DENSIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 7
|
| Other Description |
densin-180|leucine-rich repeat-containing protein 7
|
| Swissprots |
Q5VXC3 Q5VXC2 Q8WX20 Q9P2I2 Q86VE8 Q68D07 Q96NW7
|
| Accessions |
EAX06461 EAX06462 EAX06463 EAX06464 EAX06465 Q96NW7 AB037786 BAA92603 AF434715 AAL28133 AF498274 AAP06801 AK294206 BAH11697 BC080568 BC128989 AAI28990 CR749629 CAH18423 XM_011541836 XP_011540138 NM_020794 NP_065845
|
| Function |
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269|PubMed:11729199}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11729199}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}.
|
| Tissue Specificity |
Brain-specific. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:12525888}.
|