Gene Symbol | LRRC7 |
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Entrez Gene | 57554 |
Alt Symbol | DENSIN |
Species | Human |
Gene Type | protein-coding |
Description | leucine rich repeat containing 7 |
Other Description | densin-180|leucine-rich repeat-containing protein 7 |
Swissprots | Q5VXC3 Q5VXC2 Q8WX20 Q9P2I2 Q86VE8 Q68D07 Q96NW7 |
Accessions | EAX06461 EAX06462 EAX06463 EAX06464 EAX06465 Q96NW7 AB037786 BAA92603 AF434715 AAL28133 AF498274 AAP06801 AK294206 BAH11697 BC080568 BC128989 AAI28990 CR749629 CAH18423 XM_011541836 XP_011540138 NM_020794 NP_065845 |
Function | Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269|PubMed:11729199}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11729199}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. |
Tissue Specificity | Brain-specific. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:12525888}. |
densin-180 CRISPR/Cas9 KO Plasmid (h) - sc-403589 from Santa Cruz Biotechnology
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densin-180 HDR Plasmid (h) - sc-403589-HDR from Santa Cruz Biotechnology
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densin-180 Double Nickase Plasmid (h) - sc-403589-NIC from Santa Cruz Biotechnology
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densin-180 Double Nickase Plasmid (h2) - sc-403589-NIC-2 from Santa Cruz Biotechnology
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densin-180 CRISPR Activation Plasmid (h) - sc-403589-ACT from Santa Cruz Biotechnology
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densin-180 CRISPR Activation Plasmid (h2) - sc-403589-ACT-2 from Santa Cruz Biotechnology
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densin-180 Lentiviral Activation Particles (h) - sc-403589-LAC from Santa Cruz Biotechnology
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densin-180 Lentiviral Activation Particles (h2) - sc-403589-LAC-2 from Santa Cruz Biotechnology
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densin-180 siRNA (h) - sc-41995 from Santa Cruz Biotechnology
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densin-180 shRNA Plasmid (h) - sc-41995-SH from Santa Cruz Biotechnology
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densin-180 shRNA (h) Lentiviral Particles - sc-41995-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU095231 from Sigma-Aldrich
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MISSION® esiRNA - EHU093071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12762 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12762 from Sigma-Aldrich
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LRRC7 siRNA (Human) - CRJ1532 from Cohesion Biosciences
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shRNA set against Human LRRC7 (NM_020794.2) - SHH334819 from Creative biogene
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shRNA set against Human LRRC7(NM_020794.2) - SHH163687 from Creative biogene
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Human LRRC7 siRNA - orb272033 from Biorbyt
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LRRC7 shRNA Plasmid (Human) - CHJ1532 from Cohesion Biosciences
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LRRC7 miRNA 3'UTR clone - MiUTR1H-05927 from Creative biogene
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