PAPSS1

Gene Symbol PAPSS1
Entrez Gene 9061
Alt Symbol ATPSK1, PAPSS, SK1
Species Human
Gene Type protein-coding
Description 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Other Description 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1|PAPS synthase 1|PAPSS 1|SK 1|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1|sulfurylase kinase 1
Swissprots O43252 Q9P1P9 O75332 O43841 Q9UE98 Q96FB1 Q96TF4
Accessions AAC39894 AAF40235 AAY40925 AAY41043 EAX06210 O43252 AF016496 AAD09325 AF033026 AAC28429 AF105227 AAF40236 AK292774 BAF85463 AK297981 BAH12699 AU132232 BC011392 AAH11392 BC032513 AAH32513 BC040940 BC050627 AAH50627 BQ437924 BU517185 CR457028 CAG33309 DQ891043 ABM81969 DQ894222 ABM85148 Y10387 CAA71413 XM_011532400 XP_011530702 XM_011532401 XP_011530703 NM_005443 NP_005434
Function Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Tissue Specificity Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage.
Top Pathways Sulfur metabolism, Purine metabolism, Selenocompound metabolism

PAPSS 1 (A-8) - sc-376306 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PAPSS 1 (A-8): sc-376306. Western blot analysis of PAPSS 1 expression in non-transfected: sc-110760 (A) and human PAPSS 1 transfected: sc-111127 (B) 293 whole cell lysates.

PAPSS 1 (H-42) - sc-135175 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PAPSS 1 (A-2) - sc-376244 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PAPSS 1 (A-2): sc-376244. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

PAPSS 1 (K-14) - sc-47305 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PAPSS 1 (K-14): sc-47305. Western blot analysis of PAPSS 1 expression in non-transfected: sc-110760 (A) and human PAPSS 1 transfected: sc-111127 (B) 293 whole cell lysates.

PAPSS 1/2 (H-200) - sc-98993 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PAPSS 1/2 (H-200): sc-98993. Western blot analysis of PAPSS 1/2 expression in A2058 (A), MCF7 (B) and ECV304 (C) whole cell lysates.

Anti-PAPSS 1 Antibody (C-Terminus, AP) - LS-C220249 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPSS 1 Antibody (C-Terminus, APC) - LS-C220251 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPSS 1 Antibody (C-Terminus, Biotin) - LS-C220252 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPSS 1 Antibody (C-Terminus, FITC) - LS-C220253 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPSS 1 Antibody (C-Terminus, Azide-free, HRP) - LS-C220254 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPSS 1 Antibody (C-Terminus, PE) - LS-C220255 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPSS 1 Antibody (C-Terminus) - LS-C330571 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPSS 1 Antibody (aa592-624) - LS-C98545 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-PAPSS1 Antibody (C-term A607) in A2058 cell line lysates (35 ug/lane). PAPSS1(arrow) was detected using the purified antibody.

PAPSS1 Antibody - NBP1-33470 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PAPSS1 Antibody [NBP1-33470] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE; antibody diluted at 1:1000.

PAPSS1 Antibody - NBP2-19692 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PAPSS1 Antibody - NBP2-13730 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: PAPSS1 Antibody [NBP2-13730] - Staining of human cell line U-2 OS shows localization to nucleus & nucleoli.

PAPSS1 Antibody (1F4) - H00009061-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F4
Western Blot: PAPSS1 Antibody (1F4) [H00009061-M05] - Analysis of PAPSS1 expression in transfected 293T cell line by PAPSS1 monoclonal antibody (M05), clone 1F4. Lane 1: PAPSS1 transfected lysatE (68.5 KDa). Lane 2: Non-transfected lysate.

PAPSS1 Antibody - NBP2-19693 from Novus Biologicals

Host Rabbit
Clonality Polyclonal

PAPSS1 Antibody - H00009061-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

PAPSS1 Polyclonal Antibody - bs-9029R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PAPSS1 antibody produced in rabbit - SAB2700269 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PAPSS1: <B>Cat. No. SAB2700269</B>: Immunohistochemical analysis of paraffin-embedded NCI-N87 xenograft, using PAPSS1 antibody at 1:100 dilution.

ANTI-PAPSS1 (C-TERM A607) antibody produced in rabbit - SAB1304831 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PAPSS1 (C-term A607): <B>Cat. No. SAB1304831</B>: Western blot analysis of anti-PAPSS1 Antibody (C-term A607) in A2058 cell line lysates (35 μg/lane).

Anti-PAPSS1 antibody produced in rabbit - SAB2700354 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PAPSS1: <B>Cat. No. SAB2700354</B>: Immunohistochemical analysis of paraffin-embedded Colon ca, using PAPSS1 antibody at 1:500 dilution.

Anti-PAPSS1 antibody produced in rabbit - HPA049781 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PAPSS1:<B>Cat. No. HPA049781</B>: Immunohistochemical staining of human bone marrow shows strong nuclear positivity in hematopoietic cells.

Anti-PAPSS1 antibody produced in rabbit - SAB2700365 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PAPSS1: <B>Cat. No. SAB2700365</B>: Western Blot analysis of PAPSS1 in extracts from <B>Lanes</B><BR/>A. Non-transfected lysate <BR/>B. PAPSS1 transfected lysate using <B>Cat. No. SAB2700365</B> at a 1:500 dilution.
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