Gene Symbol | PAPSS1 |
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Entrez Gene | 9061 |
Alt Symbol | ATPSK1, PAPSS, SK1 |
Species | Human |
Gene Type | protein-coding |
Description | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
Other Description | 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1|PAPS synthase 1|PAPSS 1|SK 1|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1|sulfurylase kinase 1 |
Swissprots | O43252 Q9P1P9 O75332 O43841 Q9UE98 Q96FB1 Q96TF4 |
Accessions | AAC39894 AAF40235 AAY40925 AAY41043 EAX06210 O43252 AF016496 AAD09325 AF033026 AAC28429 AF105227 AAF40236 AK292774 BAF85463 AK297981 BAH12699 AU132232 BC011392 AAH11392 BC032513 AAH32513 BC040940 BC050627 AAH50627 BQ437924 BU517185 CR457028 CAG33309 DQ891043 ABM81969 DQ894222 ABM85148 Y10387 CAA71413 XM_011532400 XP_011530702 XM_011532401 XP_011530703 NM_005443 NP_005434 |
Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells. |
Tissue Specificity | Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage. |
Top Pathways | Sulfur metabolism, Purine metabolism, Selenocompound metabolism |
Human PAPSS1 protein fragment - ab133001 from Abcam
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Human PAPSS1 protein fragment - ab123177 from Abcam
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PAPSS 1 Antibody Blocking Peptide - LS-E7008 from LifeSpan Bioscience
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PAPSS1 Partial Recombinant Protein - H00009061-Q01 from Novus Biologicals
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PAPSS1 Recombinant Protein - H00009061-P01 from Novus Biologicals
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Recombinant Human PAPSS1 Protein - NBP1-78889 from Novus Biologicals
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PAPSS1-Antibody-C-term-A607-Blocking-Peptide - BP2607b from Abgent, a WuXi AppTec company
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PAPSS1-Antibody-N-term-K9-Blocking-Peptide - BP2607a from Abgent, a WuXi AppTec company
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Human PAPSS1 protein - orb168989 from Biorbyt
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PAPSS1 protein (His tag) - 80R-2132 from Fitzgerald
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PAPSS1 (24-624, His-tag) - AR50215PU-N from Acris Antibodies
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PAPSS1 (24-624, His-tag) - AR50215PU-S from Acris Antibodies
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PAPSS1 - H00009061-P01-10 from Acris Antibodies
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PAPSS1 - H00009061-P01-25 from Acris Antibodies
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PAPSS1 - H00009061-Q01-10 from Acris Antibodies
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PAPSS1 - H00009061-Q01-25 from Acris Antibodies
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3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1, Human Recombinant - 228-12387-1 from RayBiotech
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Recombinant Human 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 - 228-12387-2 from RayBiotech
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Recombinant Human 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 - 228-12387-3 from RayBiotech
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PAPSS1, 24-624aa, Human, His tag, E.coli - 01-P1390 from ARP American Research Products
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PAPSS1 fusion protein - Ag6401 from Proteintech Group
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PAPSS1 Human - ENPS-243 from NeoScientific
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Recombinant Human Parafibromin Protein - BP001722-CE45 from Syd Labs
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PAPSS1, 24-624aa, Recombinant Protein - GWB-P0648K from Genway Biotech
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Recombinant Human PAPSS1, GST-tagged - PAPSS1-1523H from Creative Biomart
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