PAPSS1
| Gene Symbol | PAPSS1 |
|---|---|
| Entrez Gene | 9061 |
| Alt Symbol | ATPSK1, PAPSS, SK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| Other Description | 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1|PAPS synthase 1|PAPSS 1|SK 1|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1|sulfurylase kinase 1 |
| Swissprots | O43252 Q9P1P9 O75332 O43841 Q9UE98 Q96FB1 Q96TF4 |
| Accessions | AAC39894 AAF40235 AAY40925 AAY41043 EAX06210 O43252 AF016496 AAD09325 AF033026 AAC28429 AF105227 AAF40236 AK292774 BAF85463 AK297981 BAH12699 AU132232 BC011392 AAH11392 BC032513 AAH32513 BC040940 BC050627 AAH50627 BQ437924 BU517185 CR457028 CAG33309 DQ891043 ABM81969 DQ894222 ABM85148 Y10387 CAA71413 XM_011532400 XP_011530702 XM_011532401 XP_011530703 NM_005443 NP_005434 |
| Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells. |
| Tissue Specificity | Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage. |
| Top Pathways | Sulfur metabolism, Purine metabolism, Selenocompound metabolism |
PAPSS 1 CRISPR/Cas9 KO Plasmid (h) - sc-405356 from Santa Cruz Biotechnology
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PAPSS 1 HDR Plasmid (h) - sc-405356-HDR from Santa Cruz Biotechnology
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PAPSS 1 Double Nickase Plasmid (h) - sc-405356-NIC from Santa Cruz Biotechnology
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PAPSS 1 Double Nickase Plasmid (h2) - sc-405356-NIC-2 from Santa Cruz Biotechnology
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PAPSS 1 CRISPR Activation Plasmid (h) - sc-405356-ACT from Santa Cruz Biotechnology
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PAPSS 1 CRISPR Activation Plasmid (h2) - sc-405356-ACT-2 from Santa Cruz Biotechnology
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PAPSS 1 Lentiviral Activation Particles (h) - sc-405356-LAC from Santa Cruz Biotechnology
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PAPSS 1 Lentiviral Activation Particles (h2) - sc-405356-LAC-2 from Santa Cruz Biotechnology
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PAPSS 1 siRNA (h) - sc-61291 from Santa Cruz Biotechnology
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PAPSS 1 shRNA Plasmid (h) - sc-61291-SH from Santa Cruz Biotechnology
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PAPSS 1 shRNA (h) Lentiviral Particles - sc-61291-V from Santa Cruz Biotechnology
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PAPSS1 RNAi - H00009061-R01V from Novus Biologicals
![Western Blot: PAPSS1 RNAi [H00009061-R01V] - Analysis of PAPSS1 over-expressed 293 cell line, cotransfected with PAPSS1 Validated Chimera RNAi or non-transfected control. Blot probed with H00009061-M05. GAPDH (36.1 kDa) used as loading control.](http://www.bioprodhub.com/system/product_images/rna_products/5/sub_1/15753_PAPSS1-RNAi-Western-Blot-H00009061-R01V-img0002.jpg)
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PAPSS1 RNAi - H00009061-R02 from Novus Biologicals
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MISSION® siRNA - SIHK1519 from Sigma-Aldrich
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MISSION® siRNA - SIHK1517 from Sigma-Aldrich
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MISSION® siRNA - SIHK1518 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16320 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16320 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05018 from Sigma-Aldrich
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PAPSS1 siRNA (Human) - CRH5981 from Cohesion Biosciences
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shRNA set against Human PAPSS1 (NM_005443.4) - SHH370548 from Creative biogene
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Human PAPSS1 siRNA - orb266483 from Biorbyt
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PAPSS1 shRNA Plasmid (Human) - CHH5981 from Cohesion Biosciences
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PAPSS1 miRNA 3'UTR clone - MiUTR1H-07500 from Creative biogene
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