| Gene Symbol | IGSF8 |
|---|---|
| Entrez Gene | 93185 |
| Alt Symbol | CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL |
| Species | Human |
| Gene Type | protein-coding |
| Description | immunoglobulin superfamily, member 8 |
| Other Description | CD81 partner 3|glu-Trp-Ile EWI motif-containing protein 2|immunoglobulin superfamily member 8|keratinocytes-associated transmembrane protein 4|prostaglandin regulatory-like protein |
| Swissprots | Q969P0 Q9BTG9 Q8NG09 Q96DP4 |
| Accessions | EAW52743 EAW52744 EAW52745 EAW52746 Q969P0 AF311906 AAM94901 AF407274 AAL01052 AK055843 BAB71027 AK090396 BAC03377 AK308115 AY044845 AAK92220 AY157579 AAO13163 BC004108 AAH04108 BC011896 AAH11896 BC023649 AAH23649 BC053881 AAH53881 BU172537 DB501388 XM_005245614 XP_005245671 XM_006711631 XP_006711694 XM_011510159 XP_011508461 NM_001206665 NP_001193594 NM_052868 NP_443100 |
| Function | May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. {ECO:0000269|PubMed:11504738, ECO:0000269|PubMed:12750295, ECO:0000269|PubMed:12752121, ECO:0000269|PubMed:14662754, ECO:0000269|PubMed:15070678}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass membrane protein. |
| Tissue Specificity | Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets. {ECO:0000269|PubMed:11504738, ECO:0000269|PubMed:12708969, ECO:0000269|PubMed:12750295}. |