| Gene Symbol |
HENMT1
|
| Entrez Gene |
113802
|
| Alt Symbol |
C1orf59, HEN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HEN1 methyltransferase homolog 1 (Arabidopsis)
|
| Other Description |
small RNA 2'-O-methyltransferase
|
| Swissprots |
A8MRR6 Q96NN0 B1AM17 Q5T8I9 Q96EJ7 B1AM16
|
| Accessions |
EAW56324 EAW56325 EAW56326 Q5T8I9 AK055087 BAB70852 AK310152 AK311542 BC012198 AAH12198 BC088366 AAH88366 BP378034 DB510959 HQ448278 ADQ32758 XM_005270411 XP_005270468 XM_011540567 XP_011538869 XM_011540568 XP_011538870 NM_001102592 NP_001096062 NM_144584 NP_653185
|
| Function |
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.
|