Gene Symbol | HENMT1 |
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Entrez Gene | 113802 |
Alt Symbol | C1orf59, HEN1 |
Species | Human |
Gene Type | protein-coding |
Description | HEN1 methyltransferase homolog 1 (Arabidopsis) |
Other Description | small RNA 2'-O-methyltransferase |
Swissprots | A8MRR6 Q96NN0 B1AM17 Q5T8I9 Q96EJ7 B1AM16 |
Accessions | EAW56324 EAW56325 EAW56326 Q5T8I9 AK055087 BAB70852 AK310152 AK311542 BC012198 AAH12198 BC088366 AAH88366 BP378034 DB510959 HQ448278 ADQ32758 XM_005270411 XP_005270468 XM_011540567 XP_011538869 XM_011540568 XP_011538870 NM_001102592 NP_001096062 NM_144584 NP_653185 |
Function | Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}. |
C1orf59 CRISPR/Cas9 KO Plasmid (h) - sc-410251 from Santa Cruz Biotechnology
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C1orf59 HDR Plasmid (h) - sc-410251-HDR from Santa Cruz Biotechnology
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C1orf59 Double Nickase Plasmid (h) - sc-410251-NIC from Santa Cruz Biotechnology
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C1orf59 Double Nickase Plasmid (h2) - sc-410251-NIC-2 from Santa Cruz Biotechnology
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C1orf59 CRISPR Activation Plasmid (h) - sc-410251-ACT from Santa Cruz Biotechnology
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C1orf59 CRISPR Activation Plasmid (h2) - sc-410251-ACT-2 from Santa Cruz Biotechnology
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C1orf59 Lentiviral Activation Particles (h) - sc-410251-LAC from Santa Cruz Biotechnology
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C1orf59 Lentiviral Activation Particles (h2) - sc-410251-LAC-2 from Santa Cruz Biotechnology
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C1orf59 siRNA (h) - sc-78563 from Santa Cruz Biotechnology
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C1orf59 shRNA Plasmid (h) - sc-78563-SH from Santa Cruz Biotechnology
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C1orf59 shRNA (h) Lentiviral Particles - sc-78563-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU039871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4656 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4656 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02302 from Sigma-Aldrich
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HENMT1 siRNA (Human) - CRJ4340 from Cohesion Biosciences
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HENMT1 - MBS8200411 from MyBioSource
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shRNA set against Human HENMT1 (NM_144584.2) - SHH311517 from Creative biogene
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shRNA set against Human C1orf59(NM_144584.2) - SHG110755 from Creative biogene
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Human HENMT1 siRNA - orb274841 from Biorbyt
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HENMT1 shRNA Plasmid (Human) - CHJ4340 from Cohesion Biosciences
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HENMT1 miRNA 3'UTR clone - MiUTR1H-01266 from Creative biogene
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HENMT1 miRNA 3'UTR clone - MiUTR3H-12332 from Creative biogene
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