| Gene Symbol | HNRNPU |
|---|---|
| Entrez Gene | 3192 |
| Alt Symbol | HNRPU, SAF-A, SAFA, U21.1, hnRNP U |
| Species | Human |
| Gene Type | protein-coding |
| Description | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) |
| Other Description | heterogeneous nuclear ribonucleoprotein U|p120 nuclear protein|pp120|scaffold attachment factor A |
| Swissprots | Q8N174 Q00839 Q9BQ09 O75507 Q96HY9 |
| Accessions | EAW77126 EAW77127 Q00839 AF068846 AAC19382 AF461014 AAP97707 AK095525 AK126868 BAG54384 AK130669 AK297119 BAG59625 AK307661 BC003367 AAH03367 BC003621 AAH03621 BC007950 AAH07950 BC015782 AAH15782 BC024767 AAH24767 BC034925 AAH34925 DQ893316 ABM84242 DQ896631 ABM87630 EU831468 ACE87155 EU831555 ACE86474 X65488 CAA46472 NM_004501 NP_004492 NM_031844 NP_114032 |
| Function | Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:19029303}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:20858735}. Cytoplasm {ECO:0000269|PubMed:19029303}. Cell surface {ECO:0000269|PubMed:7993898}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. {ECO:0000269|PubMed:17289661}. |
| Top Pathways | Spliceosome |