Gene Symbol | HNRNPU |
---|---|
Entrez Gene | 3192 |
Alt Symbol | HNRPU, SAF-A, SAFA, U21.1, hnRNP U |
Species | Human |
Gene Type | protein-coding |
Description | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) |
Other Description | heterogeneous nuclear ribonucleoprotein U|p120 nuclear protein|pp120|scaffold attachment factor A |
Swissprots | Q8N174 Q00839 Q9BQ09 O75507 Q96HY9 |
Accessions | EAW77126 EAW77127 Q00839 AF068846 AAC19382 AF461014 AAP97707 AK095525 AK126868 BAG54384 AK130669 AK297119 BAG59625 AK307661 BC003367 AAH03367 BC003621 AAH03621 BC007950 AAH07950 BC015782 AAH15782 BC024767 AAH24767 BC034925 AAH34925 DQ893316 ABM84242 DQ896631 ABM87630 EU831468 ACE87155 EU831555 ACE86474 X65488 CAA46472 NM_004501 NP_004492 NM_031844 NP_114032 |
Function | Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:19029303}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:20858735}. Cytoplasm {ECO:0000269|PubMed:19029303}. Cell surface {ECO:0000269|PubMed:7993898}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. {ECO:0000269|PubMed:17289661}. |
Top Pathways | Spliceosome |
hnRNP U CRISPR/Cas9 KO Plasmid (h) - sc-401375 from Santa Cruz Biotechnology
|
||||||||
hnRNP U HDR Plasmid (h) - sc-401375-HDR from Santa Cruz Biotechnology
|
||||||||
hnRNP U Double Nickase Plasmid (h) - sc-401375-NIC from Santa Cruz Biotechnology
|
||||||||
hnRNP U Double Nickase Plasmid (h2) - sc-401375-NIC-2 from Santa Cruz Biotechnology
|
||||||||
hnRNP U CRISPR Activation Plasmid (h) - sc-401375-ACT from Santa Cruz Biotechnology
|
||||||||
hnRNP U CRISPR Activation Plasmid (h2) - sc-401375-ACT-2 from Santa Cruz Biotechnology
|
||||||||
hnRNP U Lentiviral Activation Particles (h) - sc-401375-LAC from Santa Cruz Biotechnology
|
||||||||
hnRNP U Lentiviral Activation Particles (h2) - sc-401375-LAC-2 from Santa Cruz Biotechnology
|
||||||||
hnRNP U siRNA (h) - sc-38298 from Santa Cruz Biotechnology
|
||||||||
hnRNP U shRNA Plasmid (h) - sc-38298-SH from Santa Cruz Biotechnology
|
||||||||
hnRNP U shRNA (h) Lentiviral Particles - sc-38298-V from Santa Cruz Biotechnology
|
||||||||
hnRNP U RNAi - H00003192-R01 from Novus Biologicals
|
||||||||
hnRNP U RNAi - H00003192-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU004651 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN10211 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10211 from Sigma-Aldrich
|
||||||||
HNRNPU siRNA (Human) - CRH2182 from Cohesion Biosciences
|
||||||||
HNRNPU - MBS829053 from MyBioSource
|
||||||||
shRNA set against Human HNRNPU (NM_004501.3) - SHH313865 from Creative biogene
|
||||||||
shRNA set against Human HNRPU(NM_004501.3) - SHH127595 from Creative biogene
|
||||||||
shRNA set against Human HNRPU(NM_031844.2) - SHH127613 from Creative biogene
|
||||||||
Human HNRNPU siRNA - orb262684 from Biorbyt
|
||||||||
HNRNPU shRNA Plasmid (Human) - CHH2182 from Cohesion Biosciences
|
||||||||
HNRNPU miRNA 3'UTR clone - MiUTR1H-04639 from Creative biogene
|
||||||||
HNRNPU miRNA 3'UTR clone - MiUTR1H-04640 from Creative biogene
|