Gene Symbol | HNRNPU |
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Entrez Gene | 3192 |
Alt Symbol | HNRPU, SAF-A, SAFA, U21.1, hnRNP U |
Species | Human |
Gene Type | protein-coding |
Description | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) |
Other Description | heterogeneous nuclear ribonucleoprotein U|p120 nuclear protein|pp120|scaffold attachment factor A |
Swissprots | Q8N174 Q00839 Q9BQ09 O75507 Q96HY9 |
Accessions | EAW77126 EAW77127 Q00839 AF068846 AAC19382 AF461014 AAP97707 AK095525 AK126868 BAG54384 AK130669 AK297119 BAG59625 AK307661 BC003367 AAH03367 BC003621 AAH03621 BC007950 AAH07950 BC015782 AAH15782 BC024767 AAH24767 BC034925 AAH34925 DQ893316 ABM84242 DQ896631 ABM87630 EU831468 ACE87155 EU831555 ACE86474 X65488 CAA46472 NM_004501 NP_004492 NM_031844 NP_114032 |
Function | Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:19029303}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:20858735}. Cytoplasm {ECO:0000269|PubMed:19029303}. Cell surface {ECO:0000269|PubMed:7993898}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. {ECO:0000269|PubMed:17289661}. |
Top Pathways | Spliceosome |
hnRNP U (D-2) - sc-365852 from Santa Cruz Biotechnology
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hnRNP U (C-15) - sc-13663 from Santa Cruz Biotechnology
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hnRNP U (3G6) - sc-32315 from Santa Cruz Biotechnology
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hnRNP U (F-17) - sc-30737 from Santa Cruz Biotechnology
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hnRNP U (H-94) - sc-25374 from Santa Cruz Biotechnology
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hnRNP U (G-18) - sc-30738 from Santa Cruz Biotechnology
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Anti-hnRNP U antibody - ab122906 from Abcam
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Anti-hnRNP U antibody - ab89413 from Abcam
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Anti-hnRNP U antibody [3G6] - ab10297 from Abcam
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Anti-hnRNP U antibody [EPR12278(2)(B)] - ab180952 from Abcam
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Anti-hnRNP U antibody [EPR12279] - ab172608 from Abcam
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Anti-hnRNP U antibody - ChIP Grade - ab20666 from Abcam
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Anti-HnRNP U Antibody (aa450-500) - LS-C68202 from LifeSpan Bioscience
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Anti-HnRNP U Antibody (C-Terminus) - LS-C68203 from LifeSpan Bioscience
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Anti-HnRNP U Antibody - LS-C178255 from LifeSpan Bioscience
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Anti-HnRNP U Antibody (clone 3G6) IHC-plus⢠- LS-B8035 from LifeSpan Bioscience
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Anti-HnRNP U Antibody (aa110-159) - LS-C80348 from LifeSpan Bioscience
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Anti-HnRNP U Antibody (aa651-700) - LS-C117098 from LifeSpan Bioscience
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Anti-HnRNP U Antibody (C-Terminus) - LS-C287558 from LifeSpan Bioscience
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Anti-HnRNP U Antibody (clone 4G11) - LS-C197431 from LifeSpan Bioscience
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Anti-HnRNP U Antibody (aa450-500) - LS-C287557 from LifeSpan Bioscience
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Anti-HnRNP U Antibody (aa450-500) - LS-C285932 from LifeSpan Bioscience
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Anti-HnRNP U Antibody - LS-C332897 from LifeSpan Bioscience
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hnRNP U Antibody - NB100-2134 from Novus Biologicals
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hnRNP U Antibody - NBP1-57146 from Novus Biologicals
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