| Gene Symbol |
GTF2A1L
|
| Entrez Gene |
11036
|
| Alt Symbol |
ALF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
general transcription factor IIA, 1-like
|
| Other Description |
GTF2A1-like factor|TFIIA large subunit isoform ALF|TFIIA-alpha and beta-like factor|TFIIA-alpha/beta-like factor|general transcription factor II A, 1-like factor
|
| Swissprots |
Q53FD9 B4DY14 Q5D050 Q9UNN4
|
| Accessions |
EAX00193 EAX00194 Q9UNN4 AF106857 AAD39634 AI037906 AK223350 BAD97070 AK302220 BAG63576 BC025991 AAH25991 BC064585 AAH64585 BG207854 BG717289 DQ891566 ABM82492 DQ894756 ABM85682 HY049561 NM_001193487 NP_001180416 NM_006872 NP_006863 NM_172196
|
| Function |
May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. {ECO:0000269|PubMed:10364255}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16525715}. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.
|
| Tissue Specificity |
Testis specific. Detected in adult testis mostly in round and elongating spermatids (at protein level). Detected in testis. {ECO:0000269|PubMed:10364255, ECO:0000269|PubMed:16525715}.
|
| Top Pathways |
Viral carcinogenesis, Basal transcription factors
|
![Western Blot: GTF2A1L Overexpression Lysate [H00011036-T01] - Lane 1: ALF transfected lysate (52.69 KDa) Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/29162_GTF2A1L%2520Overexpression%2520Lysate-Western%2520Blot-H00011036-T01-img0001.jpg)