Gene Symbol | GTF2A1L |
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Entrez Gene | 11036 |
Alt Symbol | ALF |
Species | Human |
Gene Type | protein-coding |
Description | general transcription factor IIA, 1-like |
Other Description | GTF2A1-like factor|TFIIA large subunit isoform ALF|TFIIA-alpha and beta-like factor|TFIIA-alpha/beta-like factor|general transcription factor II A, 1-like factor |
Swissprots | Q53FD9 B4DY14 Q5D050 Q9UNN4 |
Accessions | EAX00193 EAX00194 Q9UNN4 AF106857 AAD39634 AI037906 AK223350 BAD97070 AK302220 BAG63576 BC025991 AAH25991 BC064585 AAH64585 BG207854 BG717289 DQ891566 ABM82492 DQ894756 ABM85682 HY049561 NM_001193487 NP_001180416 NM_006872 NP_006863 NM_172196 |
Function | May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. {ECO:0000269|PubMed:10364255}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16525715}. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa. |
Tissue Specificity | Testis specific. Detected in adult testis mostly in round and elongating spermatids (at protein level). Detected in testis. {ECO:0000269|PubMed:10364255, ECO:0000269|PubMed:16525715}. |
Top Pathways | Viral carcinogenesis, Basal transcription factors |
ALF CRISPR/Cas9 KO Plasmid (h) - sc-416285 from Santa Cruz Biotechnology
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ALF HDR Plasmid (h) - sc-416285-HDR from Santa Cruz Biotechnology
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ALF Double Nickase Plasmid (h) - sc-416285-NIC from Santa Cruz Biotechnology
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ALF Double Nickase Plasmid (h2) - sc-416285-NIC-2 from Santa Cruz Biotechnology
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ALF CRISPR Activation Plasmid (h) - sc-416285-ACT from Santa Cruz Biotechnology
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ALF CRISPR Activation Plasmid (h2) - sc-416285-ACT-2 from Santa Cruz Biotechnology
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ALF Lentiviral Activation Particles (h) - sc-416285-LAC from Santa Cruz Biotechnology
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ALF Lentiviral Activation Particles (h2) - sc-416285-LAC-2 from Santa Cruz Biotechnology
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ALF siRNA (h) - sc-72482 from Santa Cruz Biotechnology
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ALF shRNA Plasmid (h) - sc-72482-SH from Santa Cruz Biotechnology
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ALF shRNA (h) Lentiviral Particles - sc-72482-V from Santa Cruz Biotechnology
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GTF2A1L RNAi - H00011036-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9754 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9754 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00892 from Sigma-Aldrich
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GTF2A1L siRNA (Human) - CRH7542 from Cohesion Biosciences
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GTF2A1L RNAi - H00011036-R01 from Novus Biologicals
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GTF2A1L - MBS8226494 from MyBioSource
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Human GTF2A1L siRNA - orb268044 from Biorbyt
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GTF2A1L shRNA Plasmid (Human) - CHH7542 from Cohesion Biosciences
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GTF2A1L miRNA 3'UTR clone - MiUTR4H-TG04029 from Creative biogene
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