JMY

Gene Symbol	JMY
Entrez Gene	133746
Alt Symbol	WHAMM2, WHDC1L3
Species	Human
Gene Type	protein-coding
Description	junction mediating and regulatory protein, p53 cofactor
Other Description	WAS protein homology region 2 domain containing 1-like 3|junction-mediating and -regulatory protein|junction-mediating and regulatory protein
Swissprots	B5MDS2 A1L4P5 Q8N9B5 B5MDT0
Accessions	EAW95834 Q8N9B5 AK092475 AK095189 BAC04495 AL708168 BC130624 AAI30625 BM668734 BX648048 BX648731 CN372786 DA435238 DB313348 DW425980 XM_005248430 XP_005248487 XM_011543155 XP_011541457 NM_152405 NP_689618
Function	Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19287377}. Note=Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JMY (L-16) - sc-10027 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-JMY antibody - ab69945 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-JMY antibody - ab118242 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-JMY antibody - ab125190 from Abcam Prices $428.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JMY antibody - C-terminal - ab157586 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JMY antibody - C-terminal - ab190212 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-JMY antibody - N-terminal - ab174222 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa931-980) IHC-plus™ - LS-B9885 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa30-79) - LS-C151822 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa2-29, APC) - LS-C236675 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa2-29, AP) - LS-C236676 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa2-29, Biotin) - LS-C236677 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa2-29, FITC) - LS-C236678 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa2-29, PE) - LS-C236680 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa2-29, Azide-free, HRP) - LS-C249290 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa800-850) - LS-C289304 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa1-29) - LS-C322338 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa535-635) - LS-C308560 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-JMY Antibody (aa163-341) - LS-C178717 from LifeSpan Bioscience Prices $255.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa2-29) - LS-C157842 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa1-50) - LS-C286924 from LifeSpan Bioscience Prices $415.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JMY Antibody (aa1-50) - LS-C289302 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

JMY Antibody (5B6) - H00133746-M05A from Novus Biologicals Prices $349.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 5B6

JMY Antibody - NBP1-30464 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

JMY Antibody - NBP1-83478 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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