JMY

Gene Symbol	JMY
Entrez Gene	133746
Alt Symbol	WHAMM2, WHDC1L3
Species	Human
Gene Type	protein-coding
Description	junction mediating and regulatory protein, p53 cofactor
Other Description	WAS protein homology region 2 domain containing 1-like 3|junction-mediating and -regulatory protein|junction-mediating and regulatory protein
Swissprots	B5MDS2 A1L4P5 Q8N9B5 B5MDT0
Accessions	EAW95834 Q8N9B5 AK092475 AK095189 BAC04495 AL708168 BC130624 AAI30625 BM668734 BX648048 BX648731 CN372786 DA435238 DB313348 DW425980 XM_005248430 XP_005248487 XM_011543155 XP_011541457 NM_152405 NP_689618
Function	Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19287377}. Note=Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JMY protein (His-DHFR tag) - ab127477 from Abcam Category Protein Source E. coli Species Human

JMY Antibody Blocking Peptide - LS-E23623 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JMY Antibody Blocking Peptide - LS-E6588 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human JMY Protein - H00133746-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

JMY-AntibodyN-term-Blocking-peptide - BP19367a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JMY - H00133746-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

JMY - H00133746-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

JMY fusion protein - ag18735 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

JMY Blocking Peptide - CBP4042 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Bovine, Chicken, Dog, Pig

Recombinant Human Junction-mediating and -regulatory protein(JMY) ,partial - CSB-YP850838HU CSB-EP850838HU CSB-BP850838HU CSB-MP850838HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

JMY (C-terminal region) - JX3995 from ECM Biosciences Category Peptide Prices $55.00 Sizes 50 μg

JMY - TP329401 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

JMY Recombinant Protein Antigen - NBP1-83478PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

JMY Blocking Peptide - abx162535 from Abbexa Category Peptide Species Human, Mouse, Bovine, Chicken, Dog, Pig

Junction-mediating and-regulatory protein (JMY), partial, Recombinant Protein - MBS1296622 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

JMY peptide - orb256929 from Biorbyt Category Peptide

Recombinant Human JMY Protein, MYC/DDK-tagged - JMY-787H from Creative Biomart Category Protein Source HEK293 Species Human

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