| Gene Symbol |
JMY
|
| Entrez Gene |
133746
|
| Alt Symbol |
WHAMM2, WHDC1L3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
junction mediating and regulatory protein, p53 cofactor
|
| Other Description |
WAS protein homology region 2 domain containing 1-like 3|junction-mediating and -regulatory protein|junction-mediating and regulatory protein
|
| Swissprots |
B5MDS2 A1L4P5 Q8N9B5 B5MDT0
|
| Accessions |
EAW95834 Q8N9B5 AK092475 AK095189 BAC04495 AL708168 BC130624 AAI30625 BM668734 BX648048 BX648731 CN372786 DA435238 DB313348 DW425980 XM_005248430 XP_005248487 XM_011543155 XP_011541457 NM_152405 NP_689618
|
| Function |
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19287377}. Note=Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. {ECO:0000250}.
|