P2RX2
| Gene Symbol | P2RX2 |
|---|---|
| Entrez Gene | 22953 |
| Alt Symbol | DFNA41, P2X2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | purinergic receptor P2X, ligand gated ion channel, 2 |
| Other Description | ATP receptor|P2X Receptor, subunit 2|P2X purinoceptor 2|purinergic receptor P2X, ligand-gated ion channel, 2 |
| Swissprots | Q9UHD6 Q9NR37 A6NHC2 A6NIG9 A6NH93 Q9UHD5 Q9UHD7 A6NGB4 Q9Y638 Q9NR38 Q9Y637 Q9UBL9 A6NHU3 Q6V9R6 |
| Accessions | AAF19174 EAW54835 EAW54836 EAW54837 EAW54838 EAW54839 EAW54840 Q9UBL9 AF109387 AAD42947 AF109388 AAD42948 AF190822 AAF19170 AF190823 AAF19171 AF190824 AAF19172 AF190825 AAF19173 AF260426 AAF74201 AF260427 AAF74202 AF260428 AAF74203 AF260429 AAF74204 AY346374 AAQ54329 BC109200 AAI09201 HQ323686 XM_005266154 XP_005266211 XM_005266155 XP_005266212 XM_005266156 XP_005266213 XM_011534786 XP_011533088 NM_001282164 NP_001269093 NM_001282165 NP_001269094 NM_012226 NP_036358 NM_016318 NP_057402 NM_170682 NP_733782 NM_170683 NP_733783 NM_174872 NP_777361 NM_174873 NP_777362 |
| Function | Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. {ECO:0000269|PubMed:23345450}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:23345450}; Multi-pass membrane protein {ECO:0000269|PubMed:23345450}. Note=Localizes to the apical membranes of hair cells in the organ of Corti. |
| Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
P2X2 (H-116) - sc-25693 from Santa Cruz Biotechnology
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P2X2 (S-16) - sc-12212 from Santa Cruz Biotechnology
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P2X2 (V-17) - sc-12211 from Santa Cruz Biotechnology
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P2X2 (Y-25) - sc-133875 from Santa Cruz Biotechnology
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Anti-P2X2 antibody - ab10266 from Abcam
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Anti-P2X2 antibody - ab10262 from Abcam
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Anti-P2X2 antibody - ab48864 from Abcam
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Anti-P2X2 antibody - ab104621 from Abcam
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Anti-P2X2 antibody - ab28469 from Abcam
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Anti-P2X2 antibody - C-terminal - ab137794 from Abcam
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Anti-P2RX2 / P2X2 Antibody (aa81-109) - LS-C163314 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody - LS-C155588 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (aa55-104) IHC-plus⢠- LS-B990 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (aa108-157) IHC-plus⢠- LS-B6608 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (C-Terminus) - LS-C25954 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (C-Terminus) - LS-C25957 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (aa460-472) - LS-C25956 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (Cytoplasmic Domain) - LS-C94364 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (Cytoplasmic Domain) - LS-C136315 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (aa35-84) - LS-C19284 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (aa68-117) - LS-C30964 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (aa80-109, APC) - LS-C238608 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (aa80-109, AP) - LS-C238607 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (aa106-155) - LS-C31591 from LifeSpan Bioscience
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Anti-P2RX2 / P2X2 Antibody (aa108-157) - LS-C110005 from LifeSpan Bioscience
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