P2RX2
| Gene Symbol | P2RX2 |
|---|---|
| Entrez Gene | 22953 |
| Alt Symbol | DFNA41, P2X2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | purinergic receptor P2X, ligand gated ion channel, 2 |
| Other Description | ATP receptor|P2X Receptor, subunit 2|P2X purinoceptor 2|purinergic receptor P2X, ligand-gated ion channel, 2 |
| Swissprots | Q9UHD6 Q9NR37 A6NHC2 A6NIG9 A6NH93 Q9UHD5 Q9UHD7 A6NGB4 Q9Y638 Q9NR38 Q9Y637 Q9UBL9 A6NHU3 Q6V9R6 |
| Accessions | AAF19174 EAW54835 EAW54836 EAW54837 EAW54838 EAW54839 EAW54840 Q9UBL9 AF109387 AAD42947 AF109388 AAD42948 AF190822 AAF19170 AF190823 AAF19171 AF190824 AAF19172 AF190825 AAF19173 AF260426 AAF74201 AF260427 AAF74202 AF260428 AAF74203 AF260429 AAF74204 AY346374 AAQ54329 BC109200 AAI09201 HQ323686 XM_005266154 XP_005266211 XM_005266155 XP_005266212 XM_005266156 XP_005266213 XM_011534786 XP_011533088 NM_001282164 NP_001269093 NM_001282165 NP_001269094 NM_012226 NP_036358 NM_016318 NP_057402 NM_170682 NP_733782 NM_170683 NP_733783 NM_174872 NP_777361 NM_174873 NP_777362 |
| Function | Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. {ECO:0000269|PubMed:23345450}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:23345450}; Multi-pass membrane protein {ECO:0000269|PubMed:23345450}. Note=Localizes to the apical membranes of hair cells in the organ of Corti. |
| Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
P2X2 CRISPR/Cas9 KO Plasmid (h) - sc-403517 from Santa Cruz Biotechnology
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P2X2 HDR Plasmid (h) - sc-403517-HDR from Santa Cruz Biotechnology
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P2X2 Double Nickase Plasmid (h) - sc-403517-NIC from Santa Cruz Biotechnology
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P2X2 Double Nickase Plasmid (h2) - sc-403517-NIC-2 from Santa Cruz Biotechnology
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P2X2 CRISPR Activation Plasmid (h) - sc-403517-ACT from Santa Cruz Biotechnology
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P2X2 CRISPR Activation Plasmid (h2) - sc-403517-ACT-2 from Santa Cruz Biotechnology
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P2X2 Lentiviral Activation Particles (h) - sc-403517-LAC from Santa Cruz Biotechnology
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P2X2 Lentiviral Activation Particles (h2) - sc-403517-LAC-2 from Santa Cruz Biotechnology
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P2X2 siRNA (h) - sc-42565 from Santa Cruz Biotechnology
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P2X2 shRNA Plasmid (h) - sc-42565-SH from Santa Cruz Biotechnology
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P2X2 shRNA (h) Lentiviral Particles - sc-42565-V from Santa Cruz Biotechnology
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P2X2/P2RX2 RNAi - H00022953-R04 from Novus Biologicals
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P2X2/P2RX2 RNAi - H00022953-R06 from Novus Biologicals
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P2X2/P2RX2 RNAi - H00022953-R03 from Novus Biologicals
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P2X2/P2RX2 RNAi - H00022953-R01 from Novus Biologicals
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MISSION® esiRNA - EHU094171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16225 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16225 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03465 from Sigma-Aldrich
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P2RX2 siRNA (Human) - CRH7896 from Cohesion Biosciences
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P2X2/P2RX2 RNAi - H00022953-R02 from Novus Biologicals
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P2X2/P2RX2 RNAi - H00022953-R05 from Novus Biologicals
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shRNA set against Human P2RX2 (NM_174873.1) - SHH369452 from Creative biogene
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shRNA set against Human P2RX2(NM_170683.2) - SHR084642 from Creative biogene
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shRNA set against Human P2RX2(NM_012226.3) - SHR084660 from Creative biogene
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