PTEN

Gene Symbol	PTEN
Entrez Gene	5728
Alt Symbol	10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Species	Human
Gene Type	protein-coding
Description	phosphatase and tensin homolog
Other Description	MMAC1 phosphatase and tensin homolog deleted on chromosome 10|mitochondrial PTENalpha|mitochondrial phosphatase and tensin protein alpha|mutated in multiple advanced cancers 1|phosphatase and tensin-like protein|phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Swissprots	Q6ICT7 B2R904 F2YHV0 P60484
Accessions	AAC08699 AAD13528 AAD38372 AAY57327 ADM26753 ADM26754 ADM26755 ADM26756 ADM26759 AEZ67429 AEZ67430 AEZ67431 AEZ67432 AEZ67433 AEZ67434 AEZ67435 AEZ67436 AEZ67437 AEZ67438 BAA24090 CCF23296 CCV19970 CCV66764 CDI44160 EAW50172 EAW50173 EAW50174 EAW50175 P60484 AA017584 AA836562 AI825848 AK021619 AK024986 AK124525 AK130076 AK313581 BAG36351 BC005821 AAH05821 BG772190 BK008756 DAA64601 CA944942 CR450306 CAG29302 DQ892604 ABM83530 DQ895562 ABM86488 EU176713 ABW03514 HG503124 JF268690 ADZ48535 KJ534922 AHW56562 U92436 AAC51182 U93051 AAC51183 U96180 AAB66902 XM_006717926 XP_006717989 XM_011539981 XP_011538283 XM_011539982 XP_011538284 XR_945789 XR_945790 XR_945791 NM_000314 NP_000305 NM_001304717 NP_001291646 NM_001304718 NP_001291647
Function	Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K- AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator o
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Note=Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies. XIAP/BIRC4 promotes its nuclear localization.
Tissue Specificity	Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas. {ECO:0000269|PubMed:9090379}.
Top Pathways	PI3K-Akt signaling pathway, Sphingolipid signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PTEN full length protein - ab157087 from Abcam Category Protein Prices $465.00 Sizes 10 µg Source E. coli Species Human

Human PTEN full length protein - ab83649 from Abcam Category Protein Source E. coli Species Human

Human PTEN full length protein - ab84765 from Abcam Category Protein Source E. coli Species Human

PTEN peptide - ab2454 from Abcam Category Peptide

PTEN peptide - ab157804 from Abcam Category Peptide

PTEN peptide (388-400) - ab45643 from Abcam Category Peptide Species Human

Recombinant Human PTEN Protein - H00005728-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PTEN Partial Recombinant Protein - H00005728-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PTEN Peptide - NBP1-76429PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Recombinant Human PTEN Protein - NBP1-30189 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Species Human

PTEN Peptide - NBP1-76428PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

PTEN Protein - NBP1-99670 from Novus Biologicals Category Protein Prices $699.00 Sizes 5 µg Species Human

PTEN Peptide - P3270 from Novus Biologicals Category Peptide Species Human

PTEN Peptide - P3269 from Novus Biologicals Category Peptide Species Human

PTEN-Antibody-C-term-Blocking-peptide - BP13310b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-C-term-T366-Blocking-Peptide - BP18714b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-N-term-Y68-Blocking-Peptide - BP18694a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-Center-S385-Blocking-Peptide - BP18619c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-Center-240-Blocking-Peptide - BP18618c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-Center-Y336-Blocking-Peptide - BP18617c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-Center-S380-Blocking-Peptide - BP18616c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-Center-T383T382-Blocking-Peptide - BP18615c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-Center-S229T232-Blocking-Peptide - BP18875c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-Center-Y174Y176Y177Y178-Blocking-Peptide - BP18874c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTEN-Antibody-C-term-S362-Blocking-Peptide - BP18873b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Search more