| Gene Symbol |
PTEN
|
| Entrez Gene |
5728
|
| Alt Symbol |
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatase and tensin homolog
|
| Other Description |
MMAC1 phosphatase and tensin homolog deleted on chromosome 10|mitochondrial PTENalpha|mitochondrial phosphatase and tensin protein alpha|mutated in multiple advanced cancers 1|phosphatase and tensin-like protein|phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
|
| Swissprots |
Q6ICT7 B2R904 F2YHV0 P60484
|
| Accessions |
AAC08699 AAD13528 AAD38372 AAY57327 ADM26753 ADM26754 ADM26755 ADM26756 ADM26759 AEZ67429 AEZ67430 AEZ67431 AEZ67432 AEZ67433 AEZ67434 AEZ67435 AEZ67436 AEZ67437 AEZ67438 BAA24090 CCF23296 CCV19970 CCV66764 CDI44160 EAW50172 EAW50173 EAW50174 EAW50175 P60484 AA017584 AA836562 AI825848 AK021619 AK024986 AK124525 AK130076 AK313581 BAG36351 BC005821 AAH05821 BG772190 BK008756 DAA64601 CA944942 CR450306 CAG29302 DQ892604 ABM83530 DQ895562 ABM86488 EU176713 ABW03514 HG503124 JF268690 ADZ48535 KJ534922 AHW56562 U92436 AAC51182 U93051 AAC51183 U96180 AAB66902 XM_006717926 XP_006717989 XM_011539981 XP_011538283 XM_011539982 XP_011538284 XR_945789 XR_945790 XR_945791 NM_000314 NP_000305 NM_001304717 NP_001291646 NM_001304718 NP_001291647
|
| Function |
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K- AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator o
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus, PML body. Note=Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies. XIAP/BIRC4 promotes its nuclear localization.
|
| Tissue Specificity |
Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas. {ECO:0000269|PubMed:9090379}.
|
| Top Pathways |
PI3K-Akt signaling pathway, Sphingolipid signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, Prostate cancer
|
