| Gene Symbol | RALA |
|---|---|
| Entrez Gene | 5898 |
| Alt Symbol | RAL |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-ral simian leukemia viral oncogene homolog A (ras related) |
| Other Description | RAS-like protein A|Ras family small GTP binding protein RALA|ras related GTP binding protein A|ras-related protein Ral-A |
| Swissprots | A4D1W3 P11233 |
| Accessions | EAL23994 EAW94122 EAW94123 P11233 AF086082 AF493910 AAM12624 AK026850 AK308109 AU132355 BC039858 AAH39858 BM930625 DC313757 M29893 AAA36542 X15014 CAA33118 XM_006715762 XP_006715825 XM_011515466 XP_011513768 XM_011515467 XP_011513769 NM_005402 NP_005393 |
| Function | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108}. |
| Subcellular Location | Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody. |
| Top Pathways | Pancreatic cancer, Rap1 signaling pathway |