RALA

Gene Symbol	RALA
Entrez Gene	5898
Alt Symbol	RAL
Species	Human
Gene Type	protein-coding
Description	v-ral simian leukemia viral oncogene homolog A (ras related)
Other Description	RAS-like protein A|Ras family small GTP binding protein RALA|ras related GTP binding protein A|ras-related protein Ral-A
Swissprots	A4D1W3 P11233
Accessions	EAL23994 EAW94122 EAW94123 P11233 AF086082 AF493910 AAM12624 AK026850 AK308109 AU132355 BC039858 AAH39858 BM930625 DC313757 M29893 AAA36542 X15014 CAA33118 XM_006715762 XP_006715825 XM_011515466 XP_011513768 XM_011515467 XP_011513769 NM_005402 NP_005393
Function	Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108}.
Subcellular Location	Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody.
Top Pathways	Pancreatic cancer, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RALA full length protein - ab102555 from Abcam Category Protein Source E. coli Species Human

Human RALA full length protein - ab132781 from Abcam Category Protein Source Wheat germ Species Human

Human RALA protein fragment - ab159307 from Abcam Category Protein Source Wheat germ Species Human

RALA / RAL Antibody Blocking Peptide - LS-E6306 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RALA / RAL Antibody Blocking Peptide - LS-E20592 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RALA / RAL Antibody Blocking Peptide - LS-E20593 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RalA/RalB Partial Recombinant Protein - H00005898-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RalA/RalB Recombinant Protein - H00005898-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human RalA/RalB Protein - NBP1-50906 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

RALA-Antibody-C-term-Blocking-Peptide - BP18995b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RALA Protein (OPPA00156) - OPPA00156 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Recombinant Human V-ral Simian Leukemia Viral Oncogene Homolog A Protein (OPPA02483) - OPPA02483 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 25 µg Source E. Coli Species Human

Human RALA protein - orb169157 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E. coli

RALA Blocking Peptide - 33R-3493 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RALA protein (His tag) - 80R-1583 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Human RALA Protein - abx069695 from Abbexa Category Protein Source E.coli Species Human

RALA / RAL (1-203, His-tag) - AR09762PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RALA / RAL (1-203, His-tag) - AR09762PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RALA / RAL - H00005898-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

RALA / RAL - H00005898-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

RALA / RAL - H00005898-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

RALA / RAL - H00005898-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RALA / RAL - H00005898-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RALA, 1-203aa, Human, His tag, E.coli - 01-2295-A from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

V-Ral Simian Leukemia Viral Oncogene Homolog A - 20-9513 from ARP American Research Products Category Protein Prices $521.00 Sizes 50 µg Source E.coli Species Human

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