| Gene Symbol | RALA |
|---|---|
| Entrez Gene | 5898 |
| Alt Symbol | RAL |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-ral simian leukemia viral oncogene homolog A (ras related) |
| Other Description | RAS-like protein A|Ras family small GTP binding protein RALA|ras related GTP binding protein A|ras-related protein Ral-A |
| Swissprots | A4D1W3 P11233 |
| Accessions | EAL23994 EAW94122 EAW94123 P11233 AF086082 AF493910 AAM12624 AK026850 AK308109 AU132355 BC039858 AAH39858 BM930625 DC313757 M29893 AAA36542 X15014 CAA33118 XM_006715762 XP_006715825 XM_011515466 XP_011513768 XM_011515467 XP_011513769 NM_005402 NP_005393 |
| Function | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108}. |
| Subcellular Location | Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody. |
| Top Pathways | Pancreatic cancer, Rap1 signaling pathway |
Ral A CRISPR/Cas9 KO Plasmid (h) - sc-403983 from Santa Cruz Biotechnology
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Ral A HDR Plasmid (h) - sc-403983-HDR from Santa Cruz Biotechnology
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Ral A Double Nickase Plasmid (h) - sc-403983-NIC from Santa Cruz Biotechnology
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Ral A Double Nickase Plasmid (h2) - sc-403983-NIC-2 from Santa Cruz Biotechnology
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Ral A CRISPR Activation Plasmid (h) - sc-403983-ACT from Santa Cruz Biotechnology
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Ral A CRISPR Activation Plasmid (h2) - sc-403983-ACT-2 from Santa Cruz Biotechnology
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Ral A Lentiviral Activation Particles (h) - sc-403983-LAC from Santa Cruz Biotechnology
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Ral A Lentiviral Activation Particles (h2) - sc-403983-LAC-2 from Santa Cruz Biotechnology
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Ral A siRNA (h) - sc-41842 from Santa Cruz Biotechnology
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Ral A shRNA Plasmid (h) - sc-41842-SH from Santa Cruz Biotechnology
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Ral A shRNA (h) Lentiviral Particles - sc-41842-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU109011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17921 from Sigma-Aldrich
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RALA siRNA (Human) - CRH3986 from Cohesion Biosciences
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RALA - MBS8210444 from MyBioSource
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shRNA set against Human RALA (NM_005402.3) - SHH389288 from Creative biogene
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Ral A CRISPR/Cas9 KO Plasmid (h2) - sc-403983-KO-2 from Santa Cruz Biotechnology
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Ral A HDR Plasmid (h2) - sc-403983-HDR-2 from Santa Cruz Biotechnology
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Human RALA siRNA - orb264488 from Biorbyt
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RALA shRNA Plasmid (Human) - CHH3986 from Cohesion Biosciences
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RALA miRNA 3'UTR clone - MiUTR3H-01991 from Creative biogene
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