BTRC

Gene Symbol	BTRC
Entrez Gene	8945
Alt Symbol	BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP
Species	Human
Gene Type	protein-coding
Description	beta-transducin repeat containing E3 ubiquitin protein ligase
Other Description	E3RSIkappaB|F-box and WD repeats protein beta-TrCP|F-box and WD-repeat protein 1B|F-box/WD repeat-containing protein 1A|beta-TrCP1|epididymis tissue protein Li 2a|pIkappaBalpha-E3 receptor subunit
Swissprots	Q9Y213 B5MD49 Q5W142 Q9Y297 Q5W141
Accessions	EAW49770 EAW49771 EAW49772 EAW49773 EAW49774 Q9Y297 AA824369 AF101784 AAD08702 AF129530 AAF04464 AK295870 BAH12210 AK313353 BAG36155 AK313417 BAG36210 AK314880 BAG37395 AL707686 AY207475 AAO59171 AY207476 AAO59172 BC006204 BC027994 AAH27994 BC063673 BM680713 BQ188694 BX389753 CR749295 CAH18150 DA218668 GU727631 ADU87633 JF432214 ADZ15431 Y14153 CAA74572 XM_005270264 XP_005270321 XM_006718054 XP_006718117 XM_011540320 XP_011538622 XR_428727 NM_001256856 NP_001243785 NM_003939 NP_003930 NM_033637 NP_378663
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys- 21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required fo
Subcellular Location	Cytoplasm. Nucleus {ECO:0000250}.
Tissue Specificity	Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}.
Top Pathways	Wnt signaling pathway, Ubiquitin mediated proteolysis, Hedgehog signaling pathway, Circadian rhythm, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

β-TrCP (D12C8) Rabbit mAb - 11984 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D12C8

β-TrCP (D13F10) Rabbit mAb - 4394 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D13F10

β-TrCP (H-85) - sc-33213 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

β-TrCP (N-15) - sc-8862 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

β-TrCP/HOS (F-10) - sc-166492 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

β-TrCP/HOS (H-300) - sc-15354 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

β-TrCP/HOS (C-18) - sc-8863 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Beta TRCP antibody - ab188511 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Beta TRCP antibody [1D4] - ab118006 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1D4

Anti-Beta TRCP antibody - N-terminal - ab170510 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody (aa17-52, Biotin) - LS-C212987 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody (aa49-98) - LS-C145918 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody (aa17-52, APC) - LS-C212986 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody (aa17-52, FITC) - LS-C212988 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody (aa17-52, Azide-free, HRP) - LS-C212989 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody (aa17-52, PE) - LS-C212992 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody (aa24-60) - LS-C319909 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody - LS-C39733 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-BTRCP / BETA-TRCP Antibody (clone 1D4) - LS-C172702 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1D4

Anti-BTRCP / BETA-TRCP Antibody (clone 1F3) - LS-C172703 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1F3

Anti-BTRCP / BETA-TRCP Antibody - LS-C192946 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody - LS-C331612 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody (clone 1F10) - LS-C172698 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1F10

Anti-BTRCP / BETA-TRCP Antibody (aa127-156) - LS-C203776 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-BTRCP / BETA-TRCP Antibody (aa52-354, clone 3D5) - LS-C337269 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3D5

Search more