BTRC

Gene Symbol BTRC
Entrez Gene 8945
Alt Symbol BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP
Species Human
Gene Type protein-coding
Description beta-transducin repeat containing E3 ubiquitin protein ligase
Other Description E3RSIkappaB|F-box and WD repeats protein beta-TrCP|F-box and WD-repeat protein 1B|F-box/WD repeat-containing protein 1A|beta-TrCP1|epididymis tissue protein Li 2a|pIkappaBalpha-E3 receptor subunit
Swissprots Q9Y213 B5MD49 Q5W142 Q9Y297 Q5W141
Accessions EAW49770 EAW49771 EAW49772 EAW49773 EAW49774 Q9Y297 AA824369 AF101784 AAD08702 AF129530 AAF04464 AK295870 BAH12210 AK313353 BAG36155 AK313417 BAG36210 AK314880 BAG37395 AL707686 AY207475 AAO59171 AY207476 AAO59172 BC006204 BC027994 AAH27994 BC063673 BM680713 BQ188694 BX389753 CR749295 CAH18150 DA218668 GU727631 ADU87633 JF432214 ADZ15431 Y14153 CAA74572 XM_005270264 XP_005270321 XM_006718054 XP_006718117 XM_011540320 XP_011538622 XR_428727 NM_001256856 NP_001243785 NM_003939 NP_003930 NM_033637 NP_378663
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys- 21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required fo
Subcellular Location Cytoplasm. Nucleus {ECO:0000250}.
Tissue Specificity Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}.
Top Pathways Wnt signaling pathway, Ubiquitin mediated proteolysis, Hedgehog signaling pathway, Circadian rhythm, Oocyte meiosis

F-box/WD repeat-containing protein 1A (BTRC), Human, ELISA Kit - E01F0334 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

beta-transducin repeat-containing proteins (beta-TrCP) , ELISA Kit - MBS9310638 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F box/WD repeat containing protein 1A (BTRC), ELISA Kit - MBS7243140 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7218463 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7218479 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7248691 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7205192 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7229786 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7249285 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7211664 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7219621 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7253180 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7202493 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box/WD repeat-containing protein 1A (BTRC), ELISA Kit - MBS7214017 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human BTRC ELISA Kit - E014001 from Biobool

Category ELISA Kit

anti-BTRC / beta-TrCP1 antibody - ARG57309 from Arigo Biolaboratories

Category ELISA Kit

Human F-box/WD repeat-containing protein 1A (BTRC) ELISA Kit - AE62984HU from ARP American Research Products

Category ELISA Kit
Prices $549.00
Sizes 96 t
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