BTRC

Gene Symbol	BTRC
Entrez Gene	8945
Alt Symbol	BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP
Species	Human
Gene Type	protein-coding
Description	beta-transducin repeat containing E3 ubiquitin protein ligase
Other Description	E3RSIkappaB|F-box and WD repeats protein beta-TrCP|F-box and WD-repeat protein 1B|F-box/WD repeat-containing protein 1A|beta-TrCP1|epididymis tissue protein Li 2a|pIkappaBalpha-E3 receptor subunit
Swissprots	Q9Y213 B5MD49 Q5W142 Q9Y297 Q5W141
Accessions	EAW49770 EAW49771 EAW49772 EAW49773 EAW49774 Q9Y297 AA824369 AF101784 AAD08702 AF129530 AAF04464 AK295870 BAH12210 AK313353 BAG36155 AK313417 BAG36210 AK314880 BAG37395 AL707686 AY207475 AAO59171 AY207476 AAO59172 BC006204 BC027994 AAH27994 BC063673 BM680713 BQ188694 BX389753 CR749295 CAH18150 DA218668 GU727631 ADU87633 JF432214 ADZ15431 Y14153 CAA74572 XM_005270264 XP_005270321 XM_006718054 XP_006718117 XM_011540320 XP_011538622 XR_428727 NM_001256856 NP_001243785 NM_003939 NP_003930 NM_033637 NP_378663
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys- 21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required fo
Subcellular Location	Cytoplasm. Nucleus {ECO:0000250}.
Tissue Specificity	Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}.
Top Pathways	Wnt signaling pathway, Ubiquitin mediated proteolysis, Hedgehog signaling pathway, Circadian rhythm, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Beta TRCP full length protein - ab132456 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Beta TRCP peptide - ab93745 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

BTRCP / BETA-TRCP Antibody Blocking Peptide - LS-E1276 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BTRCP / BETA-TRCP Antibody Blocking Peptide - LS-E15512 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BTRCP / BETA-TRCP Antibody Blocking Peptide - LS-E15513 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human beta-TrCP1/BTRC Protein - H00008945-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BTRC-Antibody-N-term-Blocking-peptide - BP10095a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BTRC-Antibody-N-term-Blocking-peptide - BP11871a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BETA-TRCP,BTRC fusion protein - ag4139 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SCF-TrCP1 Protein Complex, Active, 10 µg - 23-026 from EMD Millipore Category Protein Prices $473.00 Sizes 10 µg

SCF-TrCP1 Protein Complex, Active, 250 µg - 23-026M from EMD Millipore Category Protein Prices $2,708.00 Sizes 250 µg

Recombinant Human F-box/WD repeat-containing protein 1A(BTRC) - CSB-YP897464HU CSB-EP897464HU CSB-BP897464HU CSB-MP897464HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BRTC12-Blocking-Peptide-N-term - BP20478a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BTRC Peptide, Human - M34GP01594H from Creative Peptides Category Peptide Source Synthetic. Species Human

F-box/WD repeat-containing protein 1A (BTRC), Recombinant Protein - MBS1338730 from MyBioSource Category Protein Prices $1,400.00, $1,400.00, $1,625.00, $1,625.00, $2,355.00, $2,355.00, $2,800.00, $2,800.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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