GNAT3

Gene Symbol GNAT3
Entrez Gene 346562
Alt Symbol GDCA
Species Human
Gene Type protein-coding
Description guanine nucleotide binding protein, alpha transducing 3
Other Description guanine nucleotide-binding protein G(t) subunit alpha-3|gustducin alpha-3 chain
Swissprots B9EJG5 A4D1B3 A4D1B2 A8MTJ3
Accessions A8MTJ3 EAL24192 EAL24193 EAW77007 BC147016 AAI47017 BC147017 AAI47018 XM_011516123 XP_011514425 XM_011516124 XP_011514426 XM_011516125 XP_011514427 NM_001102386 NP_001095856
Function Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intrace
Subcellular Location Cytoplasm {ECO:0000269|PubMed:8015379}. Note=Dual ditribution pattern; plasmalemmal pattern with apical region localization and cytosolic pattern with localization throughout the cytoplasm.
Tissue Specificity Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate and foliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected also in spermatozoa. {ECO:0000269|PubMed:16728727, ECO:0000269|PubMed:17021831, ECO:0000269|PubMed:17724332, ECO:0000269|PubMed:8015379}.
Top Pathways Taste transduction, Phototransduction, Carbohydrate digestion and absorption

Anti-GNAT3 antibody - ab113664 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry analysis of formalin-Fixed, paraffin-embedded Human Small Intestine with ab113664 at 3.75 µg/ml.

Anti-GNAT3 antibody - ab107512 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GNAT3 antibody (ab107512) at 1/100 dilution + A549 cell line lysate at 35 µg

Anti-GNAT3 / Gustducin Antibody (aa78-105, AP) - LS-C235795 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNAT3 / Gustducin Antibody (aa78-105, APC) - LS-C235796 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNAT3 / Gustducin Antibody (aa78-105, FITC) - LS-C235798 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNAT3 / Gustducin Antibody (aa78-105, Biotin) - LS-C235797 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNAT3 / Gustducin Antibody (aa78-105, Azide-free, HRP) - LS-C249093 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNAT3 / Gustducin Antibody (aa78-105, PE) - LS-C246707 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNAT3 / Gustducin Antibody (aa85-113) - LS-C321682 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNAT3 / Gustducin Antibody (aa78-105) - LS-C166554 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GNAT3 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-GNAT3 / Gustducin Antibody (aa304-318) IHC-plus™ - LS-B4942 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-GNAT3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4942 concentration 3.75 ug/ml.

GNAT3 Antibody - NBP1-20926 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry-Paraffin: GNAT3 Antibody [NBP1-20926] - (3.8ug/ml) staining of Human Small Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-GNAT3 antibody produced in rabbit - SAB4300846 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GNAT3 antibody produced in goat - SAB2501807 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

ANTI-GNAT3 (CENTER) antibody produced in rabbit - SAB1301083 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-GNAT3 (Center): <B>Cat. No. SAB1301083 </B>: GNAT3 Antibody (Center) western blot analysis in A549 cell line lysates (35 μg/lane).

GNAT3 Antibody - middle region (OAAB00497) - OAAB00497 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

GNAT3-Antibody-Center - AP10484c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
GNAT3 Antibody (Center) (Cat. #AP10484c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GNAT3 antibody detected the GNAT3 protein (arrow).

GNAT3-Antibody-internal-region - AF2670a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2670a (3.8 µg/ml) staining of paraffin embedded Human Small Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

GNAT3 antibody, Internal - GTX88624 from GeneTex

Prices $329.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-GNAT3 antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX88624

GNAT3 Antibody (OAEB00418) - OAEB00418 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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