GNAT3
| Gene Symbol | GNAT3 |
|---|---|
| Entrez Gene | 346562 |
| Alt Symbol | GDCA |
| Species | Human |
| Gene Type | protein-coding |
| Description | guanine nucleotide binding protein, alpha transducing 3 |
| Other Description | guanine nucleotide-binding protein G(t) subunit alpha-3|gustducin alpha-3 chain |
| Swissprots | B9EJG5 A4D1B3 A4D1B2 A8MTJ3 |
| Accessions | A8MTJ3 EAL24192 EAL24193 EAW77007 BC147016 AAI47017 BC147017 AAI47018 XM_011516123 XP_011514425 XM_011516124 XP_011514426 XM_011516125 XP_011514427 NM_001102386 NP_001095856 |
| Function | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intrace |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:8015379}. Note=Dual ditribution pattern; plasmalemmal pattern with apical region localization and cytosolic pattern with localization throughout the cytoplasm. |
| Tissue Specificity | Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate and foliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected also in spermatozoa. {ECO:0000269|PubMed:16728727, ECO:0000269|PubMed:17021831, ECO:0000269|PubMed:17724332, ECO:0000269|PubMed:8015379}. |
| Top Pathways | Taste transduction, Phototransduction, Carbohydrate digestion and absorption |
GNAT3 / Gustducin Antibody Blocking Peptide - LS-E247 from LifeSpan Bioscience
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GNAT3 / Gustducin Antibody Blocking Peptide - LS-E26550 from LifeSpan Bioscience
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GNAT3-Antibody-Center-Blocking-Peptide - BP10484c from Abgent, a WuXi AppTec company
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GNAT3 blocking peptide - GTX88624-PEP from GeneTex
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GNAT3 Peptide - AC21-1388-P from Abcore
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GNAT3 Peptide - 46-850P from ProSci
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GNAT3 fusion protein - Ag18121 from Proteintech Group
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Recombinant Human GNAT3, GST-tagged - GNAT3-13351H from Creative Biomart
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Recombinant Human Guanine nucleotide-binding protein G(t) subunit alpha-3(GNAT3) - CSB-YP009600HU CSB-EP009600HU CSB-BP009600HU CSB-MP009600HU from Cusabio
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GNAT3 - TP324201 from Acris Antibodies
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GNAT3, Peptide - MBS425990 from MyBioSource
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GNAT3 Peptide, Human - M34GP06392H from Creative Peptides
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Guanine nucleotide-binding protein G (t) subunit alpha-3 (GNAT3), Recombinant Protein - MBS1006079 from MyBioSource
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