Gene Symbol | CROCC |
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Entrez Gene | 9696 |
Alt Symbol | ROLT |
Species | Human |
Gene Type | protein-coding |
Description | ciliary rootlet coiled-coil, rootletin |
Other Description | Tax1-binding protein 2|ciliary rootlet coiled-coil protein|rootletin|rootletin, ciliary rootlet protein |
Swissprots | Q5TZA2 Q7Z5D7 Q7Z2L4 Q2VHY3 Q66GT7 |
Accessions | EAW94814 EAW94815 EAW94816 EAW94817 Q5TZA2 AB007914 BAA32290 AF527734 AAP85633 AK026910 BC126911 AAI26912 BC126912 AAI26913 BK005505 DAA05505 BM678006 DQ139275 ABA43896 XM_006711058 XP_006711121 XM_011542468 XP_011540770 XM_011542469 XP_011540771 XM_011542470 XP_011540772 XM_011542471 XP_011540773 XM_011542472 XP_011540774 NM_014675 NP_055490 |
Function | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis. {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858}. |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:14654843}. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase. |
Rootletin CRISPR/Cas9 KO Plasmid (h) - sc-401646 from Santa Cruz Biotechnology
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Rootletin HDR Plasmid (h) - sc-401646-HDR from Santa Cruz Biotechnology
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Rootletin Double Nickase Plasmid (h) - sc-401646-NIC from Santa Cruz Biotechnology
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Rootletin Double Nickase Plasmid (h2) - sc-401646-NIC-2 from Santa Cruz Biotechnology
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Rootletin CRISPR Activation Plasmid (h) - sc-401646-ACT from Santa Cruz Biotechnology
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Rootletin CRISPR Activation Plasmid (h2) - sc-401646-ACT-2 from Santa Cruz Biotechnology
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Rootletin Lentiviral Activation Particles (h) - sc-401646-LAC from Santa Cruz Biotechnology
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Rootletin Lentiviral Activation Particles (h2) - sc-401646-LAC-2 from Santa Cruz Biotechnology
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Rootletin siRNA (h) - sc-62960 from Santa Cruz Biotechnology
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Rootletin shRNA Plasmid (h) - sc-62960-SH from Santa Cruz Biotechnology
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Rootletin shRNA (h) Lentiviral Particles - sc-62960-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU160371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6589 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6589 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04762 from Sigma-Aldrich
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CROCC siRNA (Human) - CRH6467 from Cohesion Biosciences
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CROCC - MBS8201602 from MyBioSource
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Rootletin CRISPR/Cas9 KO Plasmid (h2) - sc-401646-KO-2 from Santa Cruz Biotechnology
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Rootletin HDR Plasmid (h2) - sc-401646-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Crocc (NM_014675.3) - SHH269741 from Creative biogene
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Human CROCC siRNA - orb266969 from Biorbyt
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CROCC shRNA Plasmid (Human) - CHH6467 from Cohesion Biosciences
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CROCC miRNA 3'UTR clone - MiUTR1H-02436 from Creative biogene
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