S1PR1

Gene Symbol	S1PR1
Entrez Gene	1901
Alt Symbol	CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1
Species	Human
Gene Type	protein-coding
Description	sphingosine-1-phosphate receptor 1
Other Description	S1P receptor 1|S1P receptor Edg-1|endothelial differentiation G-protein coupled receptor 1|endothelial differentiation, sphingolipid G-protein-coupled receptor, 1|sphingosine 1-phosphate receptor 1|sphingosine 1-phosphate receptor EDG1|sphingosine 1-phosphate receptor Edg-1
Swissprots	Q9NYN8 Q9BYY4 D3DT66 P21453
Accessions	AAK01993 EAW72927 EAW72928 P21453 AF022137 AAC51905 AF233365 AAF43420 AK297005 BAG59541 AK312493 BAG35395 BC018650 AAH18650 BI598518 BU677564 CF994197 CR541786 CAG46585 CR542269 CAG47065 CR977007 DB132417 DB572979 M31210 AAA52336 XM_006710399 XP_006710462 NM_001400 NP_001391
Function	G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation
Subcellular Location	Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl- 2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
Tissue Specificity	Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Top Pathways	Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse S1PR1 / EDG1 / S1P1 ELISA Kit (Sandwich ELISA) - LS-F6827 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.121 ng/ml Range 0.313-20 ng/ml

Mouse/Human/Rat S1PR1 / EDG1 / S1P1 ELISA Kit (Cell-Based ELISA) - LS-F2294 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Human S1PR1 / EDG1 / S1P1 ELISA Kit (Sandwich ELISA) - LS-F9051 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 0.313-20 ng/ml

Mouse S1PR1 / EDG1 / S1P1 ELISA Kit (Sandwich ELISA) - LS-F12545 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Sphingosine 1 Phosphate Receptor 1 (S1PR1), Human, ELISA Kit - SEC937Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.063ng/mL Range 0.156-10ng/mL

Sphingosine 1-phosphate receptor 1, S1PR1, Human, ELISA Kit - E1433h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Sphingosine 1-phosphate receptor type 1 (S1P1), Human, ELISA Kit - CSB-E14932h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Thymidinephosphorylase, TP, Human, ELISA Kit - CSB-E10814h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 15.6 ng/ml Range 62.5 ng/ml-4000 ng/ml

S1PR1, ELISA Kit - MBS2516202 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

S1P Receptor EDG1 Colorimetric Cell-Based ELISA Kit - CB5617 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Sphingosine 1 Phosphate, ELISA Kit - MBS062221 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/ml. Range 6.25 ng/ml - 200 ng/ml.

Sphingosine 1 Phosphate, ELISA Kit - MBS052753 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS049185 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0ng/ml. Range 6.25ng/ml-200ng/ml.

Sphingosine 1 Phosphate, ELISA Kit - MBS080165 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS067623 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS083507 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS101206 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS100958 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS063347 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS069751 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS105601 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS055177 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS058762 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS082615 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingosine 1 Phosphate, ELISA Kit - MBS064448 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0ng/ml. Range 6.25ng/ml-200ng/ml.

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