S1PR1

Gene Symbol	S1PR1
Entrez Gene	1901
Alt Symbol	CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1
Species	Human
Gene Type	protein-coding
Description	sphingosine-1-phosphate receptor 1
Other Description	S1P receptor 1|S1P receptor Edg-1|endothelial differentiation G-protein coupled receptor 1|endothelial differentiation, sphingolipid G-protein-coupled receptor, 1|sphingosine 1-phosphate receptor 1|sphingosine 1-phosphate receptor EDG1|sphingosine 1-phosphate receptor Edg-1
Swissprots	Q9NYN8 Q9BYY4 D3DT66 P21453
Accessions	AAK01993 EAW72927 EAW72928 P21453 AF022137 AAC51905 AF233365 AAF43420 AK297005 BAG59541 AK312493 BAG35395 BC018650 AAH18650 BI598518 BU677564 CF994197 CR541786 CAG46585 CR542269 CAG47065 CR977007 DB132417 DB572979 M31210 AAA52336 XM_006710399 XP_006710462 NM_001400 NP_001391
Function	G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation
Subcellular Location	Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl- 2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
Tissue Specificity	Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Top Pathways	Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EDG1 full length protein - ab132072 from Abcam Category Protein Source Wheat germ Species Human

Human EDG1 peptide - ab39763 from Abcam Category Peptide Species Human

Human EDG1 protein fragment - ab114275 from Abcam Category Protein Source Wheat germ Species Human

S1PR1 / EDG1 / S1P1 Antibody Blocking Peptide - LS-E23460 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

S1PR1 / EDG1 / S1P1 Antibody Blocking Peptide - LS-E8091 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

S1PR1 / EDG1 / S1P1 Antibody Blocking Peptide - LS-E28093 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

S1PR1 / EDG1 / S1P1 Antibody Blocking Peptide - LS-E28094 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

S1PR1 / EDG1 / S1P1 Antibody Blocking Peptide - LS-E30576 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human S1P1/EDG-1 Protein - H00001901-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human S1P1/EDG-1 Protein - H00001901-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

S1P1/EDG-1 Peptide - NBP1-76942PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

S1P1/EDG-1 Peptide - P1745 from Novus Biologicals Category Peptide Species Human

EDG1-Antibody-N-term-Blocking-Peptide - BP6137a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EDG1 / S1P1 - H00001901-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

EDG1 / S1P1 - H00001901-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EDG1 / S1P1 - H00001901-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EDG1 / S1P1 - H00001901-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EDG1 / S1P1 - H00001901-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EDG1 / S1P1 Control Peptide - AP30748CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

EDG1 / S1P1 control peptide - SP5159CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

S1P1 Peptide - 4809P from ProSci Category Peptide Species Human

Recombinant Human S1PR1 protein - S1PR1-28462TH from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human S1PR1 - S1PR1-569H from Creative Biomart Category Protein Source Mammalian Cells Species Human

TYMP 11-482aa - CMB-565 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

Recombinant Sphingosine 1 Phosphate Receptor 1 (S1PR1) - RPC937Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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